[精品][经典]热休克蛋白70在急性肾损伤中的临床价值

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1、［经典］热休克蛋白70在急性肾损伤中的临床价值热休克蛋白70在急性肾损伤中的临床价值【摘要】目的探讨热休克蛋白70在急性肾损伤的临床价值。方法选用住院新发急性肾损伤患者为对象，以健康人为对照。动态观察检测急性肾损伤患者AKI1期、AKI2期、AKI3期及对照组,使用ELISA检血HSP70、尿HSP70、血TNF-a、血IL-1等因子，应用BeckmanDUC28型自动生化分析仪测定血清BUN、Cro结果AKI患者各期血HSP70、尿HSP70、血BUN、血CR显著性高于对照组(P<0.05),AKI3期血HSP70、尿HSP70、血BUN、血CR高于AKI1期比较有统计学

2、意义(P<0.05)oAKI患者各期TNF-a、IL-1显著性高于对照组(P<0.05)oAKI3期血TNF-a、IL-1浓度低于AKI1期比较有统计学意义(P〈0・05)o急性肾损伤中血HSP70与血BUN、血CR、尿HSP70呈正相关(r=0.826,P<0.05；r=0.923,P<0.05；r=0.872,P<0.05),与TNF-a、IL-1炎性因子呈负相关(r=-0.927,P<0.05r=-0.783,P<0.05)。结论急性肾损伤HSP70表达增多反映肾损伤的严重程度，同时HSP70表达可能抑制炎症因子的的激活，启动了内源性保护机制，利于肾脏损伤的修复。❷【

3、关键词】肾损伤；急性；HSP70;TNF-aTheclinicalvalueofheat-shockprotein70inacutekidneyinjuryCENGJian,LINZhao-de,LUOFu~zhang,etal.AffiliatedNanHaiHospitalofSouthernMedicalUniversity.528200,China[Abstract]ObjectiveToapproachthetheclinicalvalueofheatshockprotein70inacutekidneyinjury.MethodsThepatientswithn

4、ewacutekidneyinjurywascellectedforresearch,andhealthyvolunteerswerecellectedasthecontro1.ThepatientswithacutekidneyinjuryinstageofAKI1,AKI2andAKI3andthevolunteersweredynamiclyobservedanddetected,allthefactors(IISP70,TNF-a,ILT,etc,)inserumandIISP70inurineweredetectedbyELISAkists,BUNandCrins

5、erumweredeterminedbyBeckmanDUC28automaticbiochemicalanalyzer・ResultsTheIISP70,BUNandCRinserumandIISP70inurineinpatientswithAKIineachstageweresignificantlyhigherthanthatincontrolgroup(P<0.05),alltheaboveindexesinpatientswithAKI3werehigherthanthatinAKI1andhadstatisticallysignificance(P<0.05)

6、.TNF-uandIL~1inseruminpatientswithAKIineachstageweresignificantlyhigherthanthatincontrolgroup(P<0.05).theconcentrationsofTNF-aandIL-1inseruminpateintswithAKI3werelowerthanthatinAKI1andhadstatisticallysignificant(P<0.05)・HSP70inserumhadpositivecorrelationwithBUNandCRinserum,andIISP70inurine

7、duringacutekidneyinjury(r二0.826,P〈0・05;r二0.923,P<0.05;r二0.872,P<0.05),buthadnegativecorrelationwithTNF-aandIL-1inserum(r二-0.927,P〈0・05r二一0.783,P〈0.05)・ConclusionTheHSP70expressionwasincreasedinacutekidneyinjury,whichreflectedtheseverityofrenalinjury.Theexpress