[经典]孟鲁司特联合布地奈德治疗支气管哮喘的临床研究

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1、［经典］孟鲁司特联合布地奈德治疗支气管哮喘的临床研究孟鲁司特联合布地奈德治疗支气管哮喘的临床研究【摘要】目的观察孟鲁司特联合布地奈德吸入治疗儿童支气管哮喘的临床疗效。方法选取中、重度支气管哮喘急性发作患儿30例，随机分对照组和治疗组,每组各15例。对照组采用激素、多索茶碱常规治疗,治疗组采用布地奈德每日两次雾化吸入、孟鲁司特4吨,1次/d睡前口服治疗。疗程均为10doid录患者临床症状缓解时间;两组治疗前和治疗后10d各进行一次肺功能测定和嗜酸性粒细胞计数，数据进行统计学分析。结果两组患儿经过治疗后肺功能FEV1/FVC%、P

2、EF均明显上升（P〈0❷05）,治疗组较对照组上升更明显（P〈0❷05）。并口治疗组患儿临床症咳嗽、喘息的缓解时间明显短于对照组（P〈0❷05）o经过治疗后两组患儿E0S计数均下降明显（P〈0❷05）,治疗组与对照组相比下降更为明显（P〈0❷05）o结论孟鲁司特联合布地奈德吸入治疗可以有效地改善中、重度哮喘患者的肺功能,缓解哮喘症状，降低EOS计数,从而有效的控制哮喘的发作。❷【关键词】支气管哮喘;孟鲁司特;布地奈德令TheClinicalObservationofMontelukastassociationwithBudes

3、onideonPatientswithBronchialAsthmaLIUHe❷lin,GANBin.DepartmentofPediatrics,XiaoganHospital,Xiaogan432100,China[Abstract】ObjectiveToobservethejointmontelukastandbudesonidetreatmentofchildbronchialasthmainclinicalefficacy❷MetheodsThirtychildbronchialasthmapatientsinmed

4、iumandsevereacuteepisodewererandomlydividedintothecontrolgroupandtreatmentgroupandtherewerefifteenpatientsineverygroup❷Thepatientsinthecontrolgroupwereappliedantibiotic、hormoneanddoxofyllineandthepatientsinthetreatmentgroupwereappliedantibiotic、budesonideatomization

5、edtwotimeseverydayandfourmildigrammontelukasttookorallyonetimeaheadsleepyeveryday❷Thetimeoftherapywastendays❷Thenwerecordedthetimethatclinicalsymptomreliefedandcarriedoutlungfunctiontestsandtheamountoftheeosinophilegranulocyte❷Laterwetakedthestatisticsanalysis❷Resul

6、tsThelungfunctionasFEV1/FVC%、PEFofthepatientsintwogroupsrisedobviously(P

7、wogroupsdecendobviouslyaftertreatment(P〈0❷05)andmoreobviouslyinthetreatmentgroup(P

8、ntoftheEOS,thusefficientlycontroltheasthmaticattack❷❷LKeywords】Bronchialasthma;Montelukast;Budesonide作者单位：432100湖北省孝感华中科技大学同济医学院附属孝感医院儿科❷❷