64例上皮性卵巢癌的临床及预后分析

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1、64例上皮性卵巢癌的临床及预后分析【关键词】上皮性卵巢癌摘要：目的：探讨影响上皮性卵巢癌预后的因素。方法：对64例卵巢上皮性癌的病例资料进行回顾性分析,26例早期（I〜II）病人以全子宫切除加双附件切除为主,38例晚期（III级及以上）以肿瘤减灭术为主，术后化疗以CAP方案为主（环磷酰胺、阿霉素、顺氯氨钳）。结果：早期患者存活率明显高于晚期患者（P〈0.01）。38例晚期患者中，理想的肿瘤减灭术（无残灶或残灶〈2cm）者存活率明显高于不理想的肿瘤减灭术残灶22cm）者（P<0.05）o术后化疗次数土6次者与〈6次者存活率斧

2、异有统计学意义（P〈0.05）。分化程度对预后有明显影响（P〈0.05）,但年龄及病理类型对预后影响差异无统计学意义（P>0.05）o肿瘤的临床分期、残灶大小及化疗次数对预后影响较大。结论：早期诊断、首次手术彻底以及化疗疗程26次是改善上皮性卵巢癌预后的关键。关键词：上皮性卵巢癌；临床分期；手术；化疗；预后Theclinicalandprognosticanalysisof64caseswithepithelialovariancancerAnagu1i?Ababaikeli,Gulina?Ababaikeli,Xuker

3、han?Saidi(DepartmentofGynecology,FirstAffiliatedHospital,XinjiangMedicalUniversity,Urumqi830054,China)Abstract:Objective:Toinvestigatetheprognosticfactorsofepithelialovariancarcinoma・Methods:Theclinicaldataandfollowupdata,of64patientswithepithelialovariancarcinoma

4、whoweretreatedinourhospitalbetweenFeb1995toFeb2005wereretrospectivelystudied.Results:Themediansurvivalof64patientswithepithelialovariancarcinomawas26months・Thesurvivalrateofpatientsinearlystage(FIGOstageIandII)wassignificantlyhigherthanthatofpatientsinadvancedstag

5、e(FIGOstageIII)(P<0.01)・Allpatientsreceivedsurgicaltherapy.Amongadvancedstageofpatients,goodcytoreductivesurgery(noresidueorresidue<2cm)wereperformedin20patientsandtheirsurvivalratewassignificantlyhigherthantheseof18unsuccessfulcases(residue22cm),26patientsunderto

6、ok6ormorecoursesofchemotherapytheirsurvivalratewasalsosignificantlyhigherthanthatof38patientswhoundertooklessthan6courses.Thesurvivalrateofpatientswithdifferentpathologicalgradehadsignificantdifference(P<0.05).Clinicalstage,sizeofresidueandthecoursesofchemotherapy

7、wereindependentprognosticfactors・Conclusion:Earlydiagnosis,primaryoptimalcytoreductivesurgeryand6ormorecoursesofchemotheraphymightimprovethesurvivalofpatientswithepithelialovariancarcinoma・keywords:epithelialovariancarcinoma;stage;operation;chemotheraphy;prognosis

8、卵巢癌发病率居妇女生殖系统恶性肿瘤第二位，死亡率居妇科恶性肿瘤Z首。近40年来，卵巢恶性肿瘤发病率有逐渐上升趋势。为了解我院对上皮性卵巢癌的临床诊治状况，并探讨影响上皮性卵巢癌的预后因素，本研究对我院1995年2月〜2005年2月间收治的64例上皮性卵巢癌患者的病例资料进行回顾性分析，现报道如下。1资料