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1、CognitionandMRImaginginAgingAdultswithoutcognitivecomplaintsPostgraduate:PengZhouTutor:YanpingWangInstituteofNeuroscienceoftheSecondAffiliatedHospitalofGuangzhouMedicalCollege,Guangzhou,China(510260)AbstractBackground:Thebrainmagneticresonanceimaging
2、ofageingpeoplewithoutcognitivecomplaintsisgenerallycharacteristicofcerebralatrophy,lacunarinfarctionandwhitematterlesionsinvariousdegrees.Cliniciansoftenstruggletoexplaintheimplicationsofthesefindingstotheirpatients-Recentstudiessuggestedthecorrelati
3、onbetweencognitivefunctionandthesethreeimagingfeatures.Thedegreeofcognitiveimpairmentiscorrelatedtowholebrainatrophy,andlocalatrophymayshowspecialcognitivedysfunction.Butitisreportedthatthecognitionoflocalbrainisdependentontheassociationbetweenwholeb
4、rainvolumeandgeneralcognitivefunction.Vascularcognitiveimpairment(VCI)derivedfromsubcorticalischemicvasculardisease(SIVD)representedimpairmentofexecutivefunctionratherthanothercognitivefunction.However,theydidn^telucidatetheirsingleorcombinedeffecton
5、cognition.Moreover,variousdetailedneuropsychologicaltestarerarelyappliedinthesestudiesandtheycarftobtaindiversedomainsofcognitivefunction.Objective:Toinvestigatetheneuroimagingfeatureinagingadultswithoutcognitivecomplaints,includingnormalpeopleandpeo
6、plewithasymptomaticpathology,andexplorethesingleandcombinedeffectsofbrainatrophy,lacunarinfarctionandwhitematterlesionsoncognitivefunctioninageingadultswithoutcognitivecomplaints.Method:Inasampleof57people,withoutcognitivecomplaints,aged60—90yearsofn
7、eurologyapartmentsofthesecondaffiliatedhospitalofGuangzhouMedicalUniversity,cerebralmagneticresonanceimagingwasperformedandadetailedneuro-psychologicaltestbatteryapplied,suchasMini-MentalStateExamination(MMSE),MontrealCognitiveAssessment(MoCA),FludOb
8、jectMemoryEvaluation(FOM),RapidVerbalRetrieve(RVR),BlockDesign(BD),DigitSpan(DS),theAlzheimer^sDiseaseAssessmentScale-CognitiveSubscaleWordRecall(ADAS-Cog-R),DigitalSymbolTest(DST).SPSS16.0isadoptedforthestatisticanalysis.Groupdifferencesofimagingwer
