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1、延边大学硕士学位论文延边地区慢性丙型肝炎患者血清中口身抗体的检测及其临床意X姓名：许顺姬中请学位级别：硕士专业：生理学指导教师：金元哲20070530英文缩略写缩略词英文全称中文全称ACLanti-cardiolipinantibody抗心卵磷脂抗体AIH-1autoimmunehepatitis自身免疫性肝炎J型ALTalanineaminotranseferase丙氨酸氨基转移酶ALBalbumin白蛋白ANAanti-nuclearantibody抗核抗体AMAanti-mitochedridantibody抗线粒体抗体ASAanti-smoothmus
2、cleantibody抗平滑肌抗体ASTaspartatearrunotranseferase天门冬氨酸转移酶HBsAgHepatitisBVirusSantigen■乙型肝炎病毒HCVViralhepatitisC丙型肝炎病毒HCV-RNAViralhepatitisC-RNA丙型肝炎病毒-核糖核酸际临床化学联合会IFCCIntematyionalFederationofClinicalChemistryIIFIndirectImmunofluorescenceAssye间接免疫荧光法IFNInterference干扰素RFRhenmatoidFactor类
3、风湿因子目的：分析延边地区慢性丙型肝炎患者血清中自身抗体阳性率及其临床意义。方法：选择100名慢性丙型肝炎患者(慢性肝炎79例,肝硬化21例)，检测自身抗体(ACL,ANA,ASA,AMA,RF)阳性率，并比较自身抗体(+)及自身抗体(・)群年龄.性别、肝功能状态。结果：慢性丙型肝炎患者血清中自身抗体至少一种阳性的62例。ACL阳性40例最多，其次为ANA阳性29例，RF阳性19例，ASA阳性8例，AMA阳性3例。另外，自身抗体阳性组和阴性组有关因素比较发现，自身抗体阳性组较阴性组年龄大(58.7岁V549.7岁)、女性多见(79・2%w46.2%)、肝功能状
4、态及肝病状态差。结论慢性丙型肝炎血清中常出现自身抗体，自身抗体出现可影响肝功能状态，加重病情，在临床诊疗中应慎重。关键词：延边地区：自身抗体：丙型慢性肝炎;Abstract：FDetectionandclinicalsignificanceofautoantibodiesinserumofpatientswithchronicHepatitisCinYanbianareaAIM:ToanalyzethepositiverateofautoantibodiesinpatientswithchronicchronicHepatitisCandtheirclini-
5、calsignifi■cances.METHODS:Thepositiverateofautoantibodiesincludinganti-cardiolipin(ALC),anti-nuclear(ANA),an-tismoothmuscle(ASA),anti-mitochondrial(AMA)an-tibodies,andrheumatiodfactor(RF)weredetectedin100patientswithchronicHepatitisC(79chronichepatitisC,21live.cirrhosis)・Andthefacto
6、rssuchasage,gender,andliverfunction,betweenpatientswithautoantibodiespositiveandnegativewerecompared.RESULTS:Theoverallpositiverateoftheautoanti-bodieswas62.0%.ThepositiverateofACL,ANA,RF,ASA,andAMAwas40.0%,29.0%,19.0%,8.0%,and3.0%,respectively.Ascomparedwiththeautoantibody-negative
7、patients>theautoantibody-positivepatientshepatitisC,21livercirrhosis)・Andthefactorssuchwereorder(5&7vs49.7),andwithworseliverfunctionanddiseasestatus.Thepositiveexpressionofautoan-tibodywasfoundhigherinfemalesthanthoseinmales(79.2%vs46.2%).CONCLUSION:Theautoantibodiesarecommonlyfoun
8、dinpatientswithchro
