病理诊断HER-2过表达乳腺癌与三阴性乳腺癌的特征比较-肿瘤医学论文

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1、病理诊断HER-2过表达乳腺癌与三阴性乳腺癌的特征比较・肿瘤医学论文病理诊断HER-2过表达乳腺癌与三阴性乳腺癌的特征比较病理诊断HER-2过表达乳腺癌与三阴性乳腺癌的特征比较周淑敏周口市中心医院病理，河南周口466000［摘要］目的比较病理诊断HER・2过表达乳腺癌与三阴性乳腺癌的特征。方法整群选取该院2013年］月一2015年5月收治182例浸润性乳腺癌患者进行硏究,根据免疫组化法检测结果分为A组(HER-2过表达乳腺癌组)与B组(三阴性乳腺癌组几对比两组淋巴结转移、组织学分级、AJCC分期情况。结果B组淋巴结转移率达到69.6%,明显高于A组47.4%

2、z差异有统计学意义(P<0.05)；且B组淋巴结转移数量“0枚所占百分率z也明显高于A组z差异有统计学意义(P<0.05XA组中3级患者所占百分率为36.8%,明显低于B组中65.2%,差异有统计学意义(Pv0.05X结论三阴性乳腺癌及HER・2过表达乳腺癌均以浸润性导管癌为主，前者三阴侵袭性更强，恶性程度更高，易发生淋巴结转移,与HER-2过表达乳腺癌相比预后更难以保证,需引起重视。关键词HER-2过表达;三阴性乳腺癌；恶性程度；转移［中图分类号］R7［文献标识码］A［文章编号］1674-0742(2015)08(c)・0018-02Comparisono

3、fPathologicalCharacteristicsBetweenHER・2Over-expressionBreastCancerandTNBCZHOUShu-minDepartmentofPathology,ZhoukouCentralHospital,Zhoukou,HenanProvince,466000China[Abstract]ObjectiveTocomparethepathologicalcharacteristicsbetweenHER-2over-expressionbreastcancerandtriple・negativebrea

4、stcancer(TNBC).Methods182patientswithinvasivebreastcanceradmittedtothehospitalbetweenJanuary2013andMay2015werestudiedanddividedintogroupA(HER-2over-expressionbreastcancergroup)andgroupB(TNBCgroup)accordingtothedetectionresultsofimmunohistochemicalassay.Thelymphnodemetastasis,histol

5、ogicalgradeandthestatusofAJCCstagingofthetwogroupswerecompared.ResultsTherateoflymphnodemetastasisingroupBreached69.6%whichwassignificantlyhigherthan47.4%ingroupA,andthedifferencewasstatisticallysign讦icant(P0.05);andthepercentageofthenumberoflymphnodemetastasisequaltoormorethan10in

6、groupBwasalsosigrdficantlyhigherthanthatingroupAandthediffereneewasstatisticallysign讦icant(P0.05).IngroupA,thepercentageofpatientsoflevelthreewas36.8%whichwassignificantlylowerthan65.2%ingroupBandthediffereneewasstatisticallysign讦icant(P0.05).ConclusionTheTNBCandHER-2over-expressio

7、nbreastcancermainlyareinfiltratingductalcarcinoma.Thetriplenegativeinvasionoftheformerisstrongerwithhigherdegreeofmalignancyandispronetoappearlymphnodemetastasis.ComparedwithHER-2over-expressionbreastcancer;itsprognosisismoredifficulttoguarantee,soattentionshouldbepaidtoit.[Keyword

8、s]HER-2over-expression;Tri