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ID:44634548
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页数:8页
时间:2019-10-24
《灯盏花素联合福辛普利治疗iga肾病的疗效观察》由会员上传分享,免费在线阅读,更多相关内容在工程资料-天天文库。
1、灯盏花素联合福辛普利治疗IgA肾病的疗效观察作者:刘晓渭,陈威,许国双,孙世仁,刘宏宝,张鹏,白淑蓉【摘要】目的:观察灯盏花素注射液联合血管紧张素转换酶抑制剂(ACEI)福辛普利治疗IgA肾病(IgAN)的效果.方法:将64例Lee氏分级U〜IV级的IgAN患者随机分为灯盏花素+ACEI组(治疗组)和ACEI组(对照组),每组32例,观察两组的疗效.疗效判定:①显效:尿蛋白定量较治疗前减少50%U上,尿沉渣检测RBC<3个/中;血肌肝异常者降至正常或较治疗前下降>20%②有效:尿蛋白定量较治疗前减少30%-50%;尿沉渣检
2、测RBC<10个/中,计数持续减少50龈上;血肌肝水平无变化或上升<20%③无效:未达到上述标准者.结果:6个疗程后,治疗组24h尿蛋白定量及血尿减轻(P&t;0.01),血白蛋白水平升高(P&t;0.01).治疗组32例中显效12例,有效16例,总有效率为87.5%;对照组32例中显效7例,有效9例,总有效率为50.0%.治疗组血液流变学指标改善,血肌肝水平,血脂下降水平优于对照组.两组患者用药后均无明显不良反应.结论:灯盏花素注射液联合福辛普利治疗IgAN安全有效,疗效明显优于单用福辛普利者.【关键词】IgA肾病;灯盏
3、花素注射液;血管紧张素转换酶抑制剂;治疗[Abstract】AIMToobservetheclinicalefficacyoffleabaneinjectioncorrtoinedwthangiotensionconvert!ngenzyrr®inhibitor(ACEI)fosinopriIinthetreatrrentofIgAnephropathy.MTHCC6:IgAnephropathycases(n=64)wthl[-IVdegreebyLeesclassificationvererandorrhydivid
4、edinto2groups:treatrrentgroup(fIeabaneandfosinopriI)andcontrolgroup(sinplefosinopriI)・Theirtherapeuticeffectsvererecordedandanalysed.TherelavantevaluationofeffectsfelIinto3types:①ExcelIence:TheurineproteinIeveldecreasedbyover50%RBCvasIessthan3per中;AbnornalScrrec
5、overedtonornalIevelordecreasedbyover20%conparedtopretreatrrent・②Efficiency:TheurineproteinIeveldecreasedby30%50%RBCvasIessthan10per申;ScrIevelshovednochangeorincreasedbyIessthan20%③Inefficacy:lbanyabovechangesvasobserved・RESULTS:SixironthsIater(30dasacourse),24h
6、urineproteinexcretioninthepatientsoftreatrrentgroupdecreasedsignificantIy(P&t;0.01vscontrolgroup),WiiIebloodalbumnincreasedgreatly(P&t;0.01vscontrolgroup)・Thetotaleffectiveratev«s87・5%intreatrrentgroup,significantlysuperiortothatofcontrolgroup(50.0%・Theparanatersi
7、nherra)rheologyvereirrprovedandserumIevelofcreatininevasregulatedappropriatelyintreatrrontgroup.Thepatientsinthe2groupshadnoadverseeffectsaftertreatrrent・CCNCLUSICNFleabaneinjectioncontoinedwthfosinopriIforIgAnephropathyissafeandeffective・Itstherapeuticeffectisb
8、etterthanthatofsinplefosinopriIadnhnistration.【Keywords】IgAnephropathy;fleabaneinjection;angiotensionconvertingenzyrreinhibitor;treatrrent0引言灯盏花素又名灯盏细辛,
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