灯盏花素联合福辛普利治疗IgA肾病的疗效观察（医学论文）.doc

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1、灯盏花素联合福辛普利治疗IgA肾病的疗效观察作者：刘晓渭，陈威，许国双，孙世仁，刘宏宝，张鹏,白淑蓉【摘要】目的：观察灯盏花素注射液联合血管紧张素转换酶抑制剂(ACEI)福辛普利治疗IgA肾病(IgAN)的效果.方法：将64例Lee氏分级U〜IV级的IgAN患者随机分为灯盏花素+ACEI组(治疗组)和ACEI组(对照组)，每组32例，观察两组的疗效.疗效判定：①显效：尿蛋白定量较治疗前减少50%以上，尿沉渣检测RBC<3个/Hp;血肌酹异常者降至正常或较治疗前下降>20%.②有效：尿蛋白定量较治疗前减少30%〜50%;尿沉渣检测RBC<10个/Hp,计数

2、持续减少50%以上；血肌肝水平无变化或上升V20%.③无效:未达到上述标准者.结果：6个疗程后，治疗组24h尿蛋白定量及血尿减轻(P<0.01),血白蛋白水平升高(P<0.01)治疗组32例中显效12例，有效16例，总有效率为87.5%;对照组32例中显效7例，有效9例，总有效率为50.0%・治疗组血液流变学指标改善，血肌肝水平，血脂下降水平优于对照组.两组患者用药后均无明显不良反应.结论：灯盏花素注射液联合福辛普利治疗IgAN安全有效，疗效明显优于单用福辛普利者.【关键词】IgA肾病；灯盏花素注射液；血管紧张素转换酶抑制剂;治疗[Abstr

3、act]AIM:Toobservetheclinicalefficacyoffleabaneinjectioncombinedwithangiotensionconvertingenzymeinhibitor(ACEI)fosinoprilinthetreatmentofIgAnephropathy.METHODS:IgAnephropathycases(n=64)withII-IVdegreebyLeesclassificationwererandomlydividedinto2groups:treatmentgroup(fleabaneandfosi

4、nopril)andcontrolgroup(simplefosinopril)・Theirtherapeuticeffectswererecordedandanalysed・Therelavantevaluationofeffectsfellinto3types:①Excellence:Theurineproteinleveldecreasedbyover50%;RBCwaslessthan3perHp;AbnormalScrrecoveredtonormallevelordecreasedbyover20%comparedtopretreatment

5、・②Efficiency:Theurineproteinleveldecreasedby30%-50%;RBCwaslessthan10perHp;Scrlevelshowednochangeorincreasedbylessthan20%・③Inefficacy:Noanyabovechangeswasobserved・RESULTS:Sixmonthslater(30dasacourse),24hurineproteinexcretioninthepatientsoftreatmentgroupdecreasedsignificantly(P<

6、0・01vscontrolgroup),whilebloodalbuminincreasedgreatly(P<0.01vscontrolgroup).Thetotaleffectiveratewas87.5%intreatmentgroup,significantlysuperiortothatofcontrolgroup(50.0%).Theparametersinhemorheologywereimprovedandserumlevelofcreatininewasregulatedappropriatelyintreatmentgroup・

7、Thepatientsinthe2groupshadnoadverseeffectsaftertreatment.CONCLUSION:FleabaneinjectioncombinedwithfosinoprilforIgAnephropathyissafeandeffective・Itstherapeuticeffectisbetterthanthatofsimplefosinopriladministration・[Keywords]IgAnephropathy;fleabaneinjection;angiotensionconvertingenz

8、ymeinhib让or;treatment0引言灯盏花素又名灯盏细辛，为菊科植物