早期高危宫颈癌术后同步放化疗的临床研究-论文

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1、早期高危宫颈癌术后同步放化疗的临床研究【摘要】目的研究早期高危宫颈癌术后不同辅助治疗的疗效和毒副反应。方法78例早期高危宫颈癌术后高危患者分为同步放化组倣化组)40例及单纯放疗组(单放组)38例,两组均于术后2〜3周开始放疗，放疗方法相同,均釆用6MV-X线四野盒式照射,常规剂量分割，盆腔中心总剂量为DT45〜50Gy。同步化放组在放疗的同吋予DDP化疗。结果放化组与单放组3年内盆腔内复发率无显著性差异,盆腔外复发率放化组低于单放组,差异有显著性意义;3年生存率分别为92.5%和76.3%,差异

2、有显著性(P<0.05)o毒副反应屮只有胃肠道反应放化组发生率高，骨髓抑制、膀胱炎和直肠炎等毒副反应与单放组比较差异无统计学意义(P>0.05),经对症处理均能耐受。结论早期高危宫颈癌术后同步放化疗治疗可提高3年生存率，且降低盆腔外的复发率，毒副反应能耐受，值得临床使用。【关键词】宫颈癌;辅助治疗;同步放化疗ClinicalReseachOfConcurrentChemoradiotherapyForTheEarlyStagePostoperativeCervicalCancerWithHigh

3、-riskFactorsQIShi-fang,LIUHua,TIANXiao-yu.DepartmentofObstetricsandGynecology,ThefirstAffiliatedHospitalofHenanUniversityofscienceandtechnology,luoyang471003,China[Abstract]ObjectiveToinvestigatetheeffectandadversereactionofconcurrentchemoradiotherap

4、yandradiotherapyonearlystagepostoperativecervicalcarcinomawithhigh-riskfactors.MethodsSeventyeightpatientsofearlystagepostoperativecervicalcarcinomawithhigh-riskfactorswererandomlydividedintotwogroups,40casesreceivedconcurrentchemoradiotherapyand38ca

5、sesreceivedradiotherapy.Twogroupsreceivedthesameradiotherapy.Theconcurrentchemoradiotherapygroupweregivencisplatinwhenirradiated.ResultsTheintrapelvicrecurrencerateoftwogroupswerenosignificantdifference.Theextrapelvicrecurrencerateoftheconcurrentchem

6、oradiotherapygroupwassignificantlowerthantheradiotherapygroup.The3-yearsurvivalratesofradiotherapygroupandconcurrentchemoradiotherapygroupwere92.5%and76.3%respectively.Thereweresignificantdiffereneebetweenthem.Onlythegastrointestinaltractreactionamon

7、gthecomplicationandadversereactioninchemoradiotherapygroupweresignificantheavierthaninradiotherapygroup.ConclusionTheeffectofconcurrentchemoradiotherapyonearlystagepostoperativecervicalcarcinomawithhigh-riskfactorscouldincreasethesurvivalrateofthepat

8、ients.Theadversereactionoftwogroupswasnosignificantdifferencebutgastrointestinaltractreaction.Thepatientscouldtolerate.Itisreasonableandeffectivetherapy.[Keywords]Cervicalcarcinomas；Adjunctivetherapy；Concurrentchemoradiotherapy宫颈癌是最常见的妇女生殖器恶性肿瘤，严重威胁妇