血液灌流抢救重度药物及农药中毒的临床观察

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1、血液灌流抢救重度约物及农药中毒的临床观察【关键词】血液灌流；重度；药物及农药中毒【摘要】目的观察血液灌流抢救重度药'物及农药中毒患者的临床疗效。方法将226例患者分为血液灌流组(HP组)和非血液灌流组(NHP组。HP组114例釆用常规治疗加血液灌流，NHP组112例仅采用常规治疗，两组进行对比研究，观察患者意识恢复的吋间，平均住院天数，病死率，并发症的发生率。结杲HP组患者意识恢复时间明显短于NHP组，平均缩短25h,缩短平均住院4d,病死率平均降低13.5%,并发症的发生率降低10.9%,两组比较均有统计学意义(P<0.05)o结论血液灌流抢救觅度药物及农药中毒的患者对在

2、短时间内淸除体内的药物及农药，迅速减轻或消除中毒症状，具有疗效快，nJ靠，副作用小，缩短病程的作用，是治疗重度药物及农药中毒最有效的方法之一。【关键词】血液灌流；重度；药物及农药中毒ClinicalobservationofhemoperfusionrescueforpatientswithseriousdrugandpesticideintoxicationLIUZiyong,HUyunyuan,LINHuiqing,etal.People'sHospitalofHuiZhouCity,GuangDong,Huizhou516002【Abstract]ObjectiveT

3、oobservetheclinicalefficacyofhemoperfusionrescueforpatientswithseriousdrugandpesticideintoxication.Methods226patientswithseriousdrugandpesticideintoxicationwererandomlydividedintotwogroups,114patientsinhemoperfusion(HP)groupweretreatedbyroutinetherapyplushemoperfusion,112patientsinnonhemop

4、erfusion(NHP)groupsweretreatedonlybyroutinetherapy.Thetimeofconsciousnessrecovery,hospitalizationtime,hospitalmortalityandincidenceofcomplicationsinbothgroupswereobservedandcompared.ResultsThetimeofconsciousnessrecoveryinHPgroupwasobviouslyshorterthanthatofNHPgroup(mean25hours),thehospital

5、izationtimewasshortenby4days,hospitalmortalityratewasdecreasedby13.5%,incidenceofcomplicationswasreducedby10.9%.Thereweresignificantdifferencesintheseparametersbetweenthetwogroups(P<0.05).ConclusionThehemoperfusionrescueforpatientswithseriousdrugandpesticideintoxicationmayremovedrugandpest

6、icideatshortertime,reduceorremovesymptomsofintoxicationquickly,havetherapeuticeffectrapidly,withreliableefficacyandfewersideeffects,andmayshortenthedurationofhospitalization.ltisoneofthebesteffectivetherapiesforseriousdrugandpesticideintoxication.【Keywords]hemoperfusion；serious；drugandpest

7、icideintoxication急性重度药物及农药中毒是急诊科常见病、多发病，由于其致病因子非常强烈，发病凶险，口服药的剂量大，种类繁多，常见很多药无特效的解毒剂而导致病情加重，救活难度大，病死率增高。近年来我科在内科综合治疗的基础上加用床边血液灌流抢救亜度药物及农药屮毒患者。提高了抢救成功率，降低了致残率及并发症的发生，取得了显著的临床疗效，现将资料总结如下。1资料与方法1.1病例选择收集2001年2月至2006年2月间我院急诊救治的急性重度纱物及农药中毒的患者共226例，分为2组。血液灌流组(HP组)114例