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1、缄沙坦联合贝那普利治疗糖尿病肾病疗效观察［摘要］目的观察颔沙坦联合贝那普利治疗糖尿病肾病的疗效。方法将20"年1月~2012年1月于我院住院的2型糖尿病肾病患者80例随机分为贝那普利组（27例X颂沙坦组（26例）.颂沙坦联合贝那普利组（联合组，27例）,三组患者均连续给予控制血糖和血压治疗2周在此基础上，三组分别采用贝那普利、颂沙坦、颂沙坦联合贝那普利治疗,均连续治疗12周。对所有患者的血压、空腹血糖（FPG,血清电解质（K+X血尿素氮（BUN）及血肌酹（SCr,肌酹清除率（Ccr）及24h尿蛋白进行观察，同时记录不良反应。结果三组治
2、疗前后血压、24h尿蛋白治疗后与治疗前比较，差异均有统计学意义（P<0.05）,治疗后联合组与与贝那普利组、纟颉沙坦组比较，差异有统计学意义（P<0.05三组治疗前后FPG、K+、BUN、SCr、Ccr及不良反应的比较差异均无统计学意义（P>0.05）b结论颔沙坦联合贝那普利治疗糖尿病肾病患者的血压、尿蛋白方面疗效较单一用药好，临床可安全应用。［关键词］纟颉沙坦；贝那普利；糖尿病肾病；临床疗效［中图分类号］R587.2只692.3［文献标识码］A［文章编号］1673-7210(2012)07(b)-0065-02Clinicalob
3、servationofValsartancombinedwithBenazeprilinthetreatmentofdiabeticnephropathyLIXionglCHENTing2CAIDelZHONGZhi1DepartmentofPharmacy,theAffiliatedHospitalofGuangdongMedicalCollege,GuangdongProvince,Zhanjiang524001,China;2.DepartmentofNephrology,theAffiliatedHospitalofGuang
4、dongMedicalCollege,GuangdongProvinee,Zhanjiang524001,China[Abstract]ObjectiveToobservetheeffectofValsartancombinedwithBenazeprilinthetreatmentofdiabeticnephropathy.Methods80patientswithdiabeticnephropathyfromJanuary2011toJanuary2012inourhospitalweredividedintothreegroup
5、s:Valsartangroup(27cases),Benazeprilgroup(26cases),ValsartancombinedwithBenazeprilgroup(combinedgroup,27cases).Threegroupsofpatientswerecontinuouslygiventocontrolbloodsugarandbloodpressuretreatmentfor2weeks,onthebasis,Valsartan,Benazeprilandcombineddrugsweregiventhethre
6、egroups,andthetotaltimeofthetreatmentwas12weeks.Andbloodpressure,fastingplasmaglucose(FPG),serumelectrolytes(K+),bloodureanitrogen(BUN)andserumcreatinine(SCr),creatinineclearaneerate(Ccr)and24hurinaryproteinforallpatientswereobserved,andtheadversereactionswererecorded,R
7、esultsBeforeandaftertreatmentinthreegroups,bloodpressure,24hurinaryproteinaftertreatmentwerecompared,thereweresignificantdifferences(P<0.05),thecombinedgroupcomparedwiththeBenazeprilgroupandValsartangroup,thereweresignificantdifferences(P<0.05).FPG,K+,BUN,andSCrandCcran
8、dadversereactionsinthethreegroupsbeforeandaftertreatmentshowednosignificantdifferences(P>0.05).ConclusionValsa
