[经典]甲泼尼龙治疗重症急性胰腺炎疗效分析

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1、甲泼尼龙治疗重症急性胰腺炎疗效分析【摘要】目的探讨甲泼尼龙对重症急性胰腺炎的治疗作用。方法回顾分析辽宁医学院附属第三医院2004年1月至2007年12月收治的重症急性胰腺炎患者62例，其中常规治疗组32例（对照组），甲泼尼龙治疗组30例（治疗组）。对比两组患者腹痛、腹胀缓解时间，血、尿淀粉酶恢复正常时间，腹水消退时间，病死率，并发症发生率，住院时间等，以评价甲泼尼龙治疗重症急性胰腺炎的临床疗效。结果治疗组腹痛、腹胀缓解时间，血、尿淀粉酶恢复正常时间，腹水消退时间，住院时间较对照组明显缩短（P〈0・0

2、5）；治疗组的主要并发症如ARDS,MODS,胰腺假性囊肿和病死率明显低于对照组（P〈0・05）。但是，两组患者之间合并胰周脓肿及肝功能不全、肾功能不全、心功能不全恢复正常时间的比较，差异无统计学意义（P>0・05）o结论甲泼尼龙对重症急性胰腺炎有明显临床疗效，能够降低病死率，减少并发症，缩短住院时间。❷【关键词】甲泼尼龙；重症急性胰腺炎；疗效❷❷TheefficacyanalysisofmethylprednisolonetreatmentofsevereacutepancreatitisZHAO

3、Chi-long,XIEYi-ming・DepartmentofGeneralSurgery,ThirdAffiliatedHospitalofLiaoningCollegeofMedicine,Liaoning121000,China令[Abstract]ObjectiveToinvestigatethetherapeuticeffectsofmethylprednisolone（MP）inthetreatmentofthepatientswithsevereacutepancreatitis（S

4、AP）・Methods62paitentswithsevereacutepancreatitisinourdepartmentfromjanuary2004todecember2007includingtwogroups：conventiongroup（controlgroup,n=32）andmethylprednisolonegroup(treatmentgroup,n二30)・Toreviewedanalyzedandcomparedwiththerelievetimeofabdominalp

5、ainabdominaldistention,theregressiontimeofabdominaldropsy,thehospitalstay(day),themorbidityofcomplications,thecasefatality,therestoretimeofhemodiastase,urinaryamylase.ResultsTherelievetimeofabdominalpainabdominaldistention,theregressiontimeofabdominald

6、ropsy,thehospitalstay,therestoretimeofhemodiastase,urinaryamylaseintreatmentgroupweremarkedlyshorterthanthoseincontrolgroup(P<0.05),thecasefatality,themorbidityofsuchcomplicationsasARDS,MODS,pancreaticpesudocyst,intreatmentgroupwasmarkedlylowerthanthat

7、inthecontrolgroup(P<0.05)・Buttherestoretimeofhepaticinadequacy,therenalinadequacy,thecardiacinsufficiencyandtheparapancreaticabscessbetweentwogroupshadnodifferences(P>0.05)・ConelusionsThemedicinemethylprednisolonehasgoodtherapeuticeffectsinthetreatment

8、ofthepatientswithSAP・Itcandecreasethecasefatality,reducethehospitalstaysandcomplications・❷[Keywords]Methylprednisolone;Severeacutepancreatitis;Therapeuticeffects急性胰腺炎(acutepancreatitis,AP)是外科常见的急腹症之一，发病率较高，临床上根据病情轻重分为轻型急性胰腺炎(miIdacutepa