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1、阿托伐他汀对急性冠脉综合征患者高敏一C反应蛋白及血脂水平的影响王国敏海南省琼海市人民医院急诊科海南琼海571400【摘要】目的：观察高皱C反应蛋口(hs—CRP)及血脂水平的变化，评估阿托伐他汀治疗急性冠脉综合症(ACS)患者的疗效。方法：选择72例急性冠脉综合症患者，随机分为治疗组及对照组(每组各36例)，治疗组用常规加阿托伐他汀20mg?d-l对照组仅为常规治疗。治疗前、1个月、3个月分别检测两组患者hs—CRP和血脂水平，并对比分析，随访两组主要心血管事件(MACE)包括全因性死亡、非致死性心肌梗
2、死、靶血管再次血运重建。随访为期1年。结果：治疗组治疗1个月后hs—CRP、总胆固醇明显低于治疗前水平(P<0.05),治疗3个月后两者较治疗前更明显降低(P<0.01)；治疗组治疗3个月后，低密度胆固醇、甘油三酯均较治疗前明显降低(P<0.05),高密度胆固醇治疗前后变化不明显。而对照组hs-CRP及血脂与治疗前相比，均无明显变化。治疗组MACE发生率明显低于对照组(P<0.05)。结论：阿托伐他汀降低ACS患者hs—CRP及总胆固醇、低密度胆固醇及甘油三酯水平，有助于减少MA
3、CE发生率。【关键词】阿托伐他汀；急性冠脉综合症；高皱CRP；血脂【屮图分类号1R541.4【文献标识码］B【文章编号11674-8999(2015)8-0203-02Influencesofatorvastatintherapyonhs-CRPandlipidslevelsinpatientswithacutecoronarysyndrome(ACS)WANGGuoMin(DepartmentofEmergency,ThePeople’SHospitalofQionghai,Hainan5
4、71400,China)[Abstract]Objective：Toobservethechangesofhigh-sensitivityCreactiveprotein(hs・CRP)、lipidslevels,andtoevaluatetheeffectofatorvastatintherapyinpatientswithACS.Methods：Seventy-twopatientswithACSwererandomlydividedintotreatmentandcontrolgroups(36c
5、aseseach),treatmentgroupwithatorvastatintherapy(20mg?d-l)plusroutinetherapy,whilecontrolgroupweretreatedwithroutinetherapyonly,hs-CRPandlipidslevelsintwogroupsweremeasuredatbeforetherapy^1month^3months、aftertreatment.Theresultswerecompared.Theincideneeof
6、majoradversecardiacevents(MACE)includingdeath,nonfatalmyocardialinfarction,andtargetvesselrevascularizationwerefollowedfor1yearaftertreatment.Results：At1monthaftertreatment,thelevelsofhs一CRPandtotalcholesterol(TC)intreatmentgroupswerelowerthanthoseofbefo
7、retreatment(P<0.05),aftertreatmentfor3months,thelevelsofhs-CRPandTCweresignificantlydecreasedthanthoseofbeforetreatment(P<0.01).At3monthsaftertreatment,thelevelsoflowdensitylipoproteincholesterol(LDL-C)andtriglyceride(TG)intreatmentgroupwerelowerth
8、anthoseofbeforetreatment(P<0.05),whilhighdensitylipoproteincholesterol(HDL-C)hadnosignificantlydiffereneebeforeandaftertreatment.Therewerenodifferencesincontrolgroupbeforeandaftertreatment-TheoccurreneeratesofMACEintrea
