资源描述：
《微乳透皮研究》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、四川大学博硕士研究生课程考试试卷姓名王爽学号2017224050055学院（所、中心）药学院专业药齐IJ考试课程名称科学论文写作考试方式□笔试□口试丿撰写论文任课教师尹宗宁老师考试成绩考试时间四川大学研究生院制MicroemulsionBasedTransdermalDrugDeliveryofCannabidiolSpecificAimsSeborrheicdermatitis,alsoknownasseborrheiceczema,isachronicpapularscalyinflammatorydermatosisoccurringintherichp
2、artofthesebaceousglands.Thediseaseismorecommoninadultsandnewborns,goodhairattheheadandtrunkandsebaceousglandrichareas111.Cannabidiolisasecondarymetaboliteofcannabinol,whichhasnonerveactivityandnoaddiction.Ithasmedicinalvalueinanti-tumor,nervoussystemprotection,immunemetabolismregulat
3、ion,protectionofcardiovascularfunction,liverprotection,antibacterialandanti-inflammatoryandanti-oxidation^"].Objective:todevelopatransdermaldrugdeliverysystemformicroemulsionseborrheicdermatitis.MicroemulsionisacertainamountofCannabidiolformula,differentconcentrationsofpolysorbate80a
4、ssurfactant,isopropylmyristate,isopropylalcoholascosurfactant.ThepH,thedropletsize,thePDI,theviscosityandthesurfacemorphologywerecharacterized.Theaverageparticlesizeofthemicroemulsionis100+10nm,andthePDIis0.75intheuniformrangeofmicroemulsion.Theviscosityoftherheologydatawasevaluateda
5、ndthemicroemulsionwasfoundtobealowviscositysystem.ThehighestcontentofcannabinolinmicroemulsionwasS%・TheTEMimageofthemicroemulsionshowsthesphericalanduniformboundaryoftheoilparticles.Thestudyofskindiffusionclearlyillustratestheenhancedabilityofmicroemulsiontopasstheskinthroughthetrans
6、dermaldelivery.AboutXX%cannabidiolpermeationwasobservedfrommicroemulsion.SkinirritationhasconfirmedthatuptoX%cannabidiolcanbesafelyappliedtotheskin.Thestudyshowsthatthecannabidiolmicroemulsionsystemisexpectedtobethecarrierofpsoriasistransdermaldelivery・BackgroundandSignificance:Micro
7、emulsionsareopticallytransparent,lowviscosity,andthermodynamicallystabledispersionsofoilandwaterstabilizedbyaninterfacialfilmofasurfactant,usuallyincombinationwithacosurfactant.Inpharmaceutics,microemulsionsareusedasvehiclestodelivermanykindsofdrugsbecauseoftheirthermodynamicstabilit
8、y,easeofprep
