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1、四川大学博硕士研究生课程考试试卷姓名王爽学号2017224050055学院(所、中心)药学院专业药齐IJ考试课程名称科学论文写作考试方式□笔试□口试丿撰写论文任课教师尹宗宁老师考试成绩考试时间四川大学研究生院制MicroemulsionBasedTransdermalDrugDeliveryofCannabidiolSpecificAimsSeborrheicdermatitis,alsoknownasseborrheiceczema,isachronicpapularscalyinflammatorydermatosisoccurringintherichp
2、artofthesebaceousglands.Thediseaseismorecommoninadultsandnewborns,goodhairattheheadandtrunkandsebaceousglandrichareas111.Cannabidiolisasecondarymetaboliteofcannabinol,whichhasnonerveactivityandnoaddiction.Ithasmedicinalvalueinanti-tumor,nervoussystemprotection,immunemetabolismregulat
3、ion,protectionofcardiovascularfunction,liverprotection,antibacterialandanti-inflammatoryandanti-oxidation^"].Objective:todevelopatransdermaldrugdeliverysystemformicroemulsionseborrheicdermatitis.MicroemulsionisacertainamountofCannabidiolformula,differentconcentrationsofpolysorbate80a
4、ssurfactant,isopropylmyristate,isopropylalcoholascosurfactant.ThepH,thedropletsize,thePDI,theviscosityandthesurfacemorphologywerecharacterized.Theaverageparticlesizeofthemicroemulsionis100+10nm,andthePDIis0.75intheuniformrangeofmicroemulsion.Theviscosityoftherheologydatawasevaluateda
5、ndthemicroemulsionwasfoundtobealowviscositysystem.ThehighestcontentofcannabinolinmicroemulsionwasS%・TheTEMimageofthemicroemulsionshowsthesphericalanduniformboundaryoftheoilparticles.Thestudyofskindiffusionclearlyillustratestheenhancedabilityofmicroemulsiontopasstheskinthroughthetrans
6、dermaldelivery.AboutXX%cannabidiolpermeationwasobservedfrommicroemulsion.SkinirritationhasconfirmedthatuptoX%cannabidiolcanbesafelyappliedtotheskin.Thestudyshowsthatthecannabidiolmicroemulsionsystemisexpectedtobethecarrierofpsoriasistransdermaldelivery・BackgroundandSignificance:Micro
7、emulsionsareopticallytransparent,lowviscosity,andthermodynamicallystabledispersionsofoilandwaterstabilizedbyaninterfacialfilmofasurfactant,usuallyincombinationwithacosurfactant.Inpharmaceutics,microemulsionsareusedasvehiclestodelivermanykindsofdrugsbecauseoftheirthermodynamicstabilit
8、y,easeofprep