多西他赛和奈达铂同步或序贯放射治疗中晚期食管癌的对比研究

《多西他赛和奈达铂同步或序贯放射治疗中晚期食管癌的对比研究》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。

1、(临床应用研老/伦着』多西他赛和奈达钳同步或序贯放射治疗中晚期食管癌的对比研究王文明卢琳杜国威青岛大学医学院第二附属医院肿瘤科，山东青岛266042【摘要】目的：评价多西他赛和奈达钳同步放化疗与序贯放化疗治疗中晚期食管癌的疗效和毒副作用。方法：89例中晚期食管癌总者随机分成两组：观察组(同步放化疗〉45例，放疗同时行多西他赛和奈达餡方案化疗2个周期；对照组(序贯放化疗)44例，先单纯行放疗，放疗结東后序貫多西他赛和奈达饷方案化疗2个周期。放疗均采用克线加速器(6MVX射线)调良适形放疗(IMRT).放疗剂量达(60〜64)Gy/(30〜32)次.结果：观察组近

2、期有效率为8&9%,明显高于对照组的70.5%,差异有统计学意义，PV0.05。1、2年生存率观察组为84.4%和6&9%,明显高于对照组的65.9%和45.5%,差异有统计学意义.PV0.05。观察组恶心、呕吐及急性白细胞下降发生率高于对照组(PV0.05),但可以耐受。其他#剖作用差异无统计学意义，P>0・05。结论：多西他赛和奈达柏同步放化疗治疗中晚期食管癌，能提高近期疗效及1、2年生存率•急性毒副作用略增加，但可以耐受。【关键词】食管肿瘤；序贯放化疗；同步放化疗；奈达伯；多西他赛中华肿瘤防治杂志,2012,19(18)J407—1409Contrast

3、ivestudyonconcurrentchemoradiotherapyandsequentialchemoradiotherapywithdocetaxelandnadaplatinforlocaladvancedesophagealcancerWANGWen-ming>LULin9DUGuo-zveiDepartmentofOncology^SecondAffiliatedHospital^MedicalCollegeofQingdaoUniversity^Qingdao266042,P.R.China[ABSTRACT]OBJECTIVE：Toeval

4、uatetheclinicalcurativeeffectandtoxicityofconcurrentversussequentialchemoradiotherapywithdocetaxelandnadaplatinforlocaladvancedesophagealcancer.METHODS:Eighty-ninepatientswithlocaladvancedesophagealcancerwererandomlydividedintothestudygroup(n=45)andthecontrolgroup(n=44)・Thestud-ygr

5、oupreceivedradiotherapyconcurrentwithtwocyclesofchemotherapywithdocetaxelandnadaplatin・Thecontrolgroupreceivedradiotherapyfirstonly♦thenreceivedtwocyclesofsequentialchemotherapywithdocetaxelandnadaplatin.AllpatientsreceivedIMRTusing6MVX-ray,andthetotaldoseswere(60—64)Gy/(30—32)f.RES

6、ULTS:Theresponseratewashighterinthestudygroup(88.9%)thanthatthecontrolgroup(70.5%,andtherewassignificantdifferencebetweentwogroups(PV0.05).The1・and2-yearsurvivalratesforthepatientswere84.4%and68.9%inthestudygroupand65.9%and45.5%inthecontrolgroup>respectively.Thereweresignificantdif

7、ference(P<0.05).Morenauseaandvomitingoccurredinthestudygroupthanthecontrolgroup(P<0.05).Theincidenceofacutebonemarrowinhibitionwashigherinthestudygroupthanthecontrolgroup(PV0.05)9buttheycouldbetolerated.Othertoxicitieshadnosignificantdifferencebetweenthetwogroups(P>0.05).CONCLUSIONS

8、:Docetaxelandnadapl