临床医学论文益肾活血方配合激素和环磷酰胺治疗狼疮肾炎的临床观察

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1、临床医学论文•益肾活血方配合激素和环磷酰胺治疗狼疮肾炎的临床观察作者：向彩春史伟王起航向清【摘要】目的观察益肾活血方治疗狼疮肾炎(LN)的临床疗效。方法将60例狼疮肾炎患者随机分为2组。对照组30例予激素和环磷酰胺；治疗组30例在对照组治疗基础上加用益肾活血方，每日1剂，水煎分2次服。2组均1个月为1个疗程，3个疗程后观察治疗前后LN的活动指标(发热、皮疹、关节痛、脫发)，尿蛋白，血尿，肾功能，肝功能，血清抗双链DNA(ds-DNA)滴度，补体C3、C4等变化情况。结果治疗组总有效率93.3%对照组总有效率80.0%2组比较差异有统计学意

2、义(P<0.05)；2组治疗后24h尿蛋白、血清白蛋白、血肌肝、尿素氮、丙氨酸氨基转移酶、抗ds・DNA抗体滴度及C3、C4与本组治疗前比较差异均有统计学意义(PcO.05，P<0.01)，2组治疗后比较差异均有统计学意义(P<0.05)，治疗组均优于对照组；2组不良反应发生率和复发率比较差异均有统计学意义(P<0.05)，治疗组低于对照组。结论益肾活血方治疗狼疮肾炎疗效确切，并可降低西药副作用，减少并发症，降低复发率。【关键词】狼疮肾炎中西医结合疗法ClinicalobservationontherapeuticeffectofYish

3、enhuoxuedecoctionintegratedwithwesternmedicineonlupusnephritis[AbstracI】ObjectiveToobservethetherapeuticeffectofYishcnhuoxucdecoctioncombinedwithwesternmedicineonlupusnephritis.Methods60patientswithlupusnephritis(LN)wererandomlydividedintotwogroups・30patientsincontrolgrou

4、pweretreatedbyhormonesandcyclophosphamide；Theother30patientsintreatmentgroupweretreatedsimilarlyplusYiqihuoxuedecoction.TheactivityparametersofLN,urinaryprotein,liverfunction,serumanti・ds・DNA,completeC3,C4wereevaluatedinbothgroupsbeforeandafterthetreatment・ResultsThetotal

5、effectiverateintreatmentgroupwas93.3%jwhichwas80%incontrolgroup,therewasasignificantdifferencebetweentwogroups(P<0.05)；thereweresignificantdifferencesinurinaryprotein,1iverfundion,serumanti-ds-DNA,completeC3,C4inbothgroupsbeforeandafterthetreatment(P<0.05orP<0.01);afterth

6、etreatmenttherewasasignificantdifferenceintheseparametersbetweentreatmentgroupandcontrolgroup(PvO.O5),andthoseintreatmentgroupweresuperiortothoseofcontrolgroup»thereweresignificantdifferencesintheincidenceofadversereactionandrecurrenceaftertreatmentbetweentwogroups(P<0.05

7、),andthoseintreatmentgroupwas1owerthanthoseincontrolgroup.ConclusionYiqihuoxuedecoctioniseffectiveintreatinglupusnephritis,whichcanreducethesideeffectsofwesternmedicinesanddecreasecomplicationsandrecurrentrate.[Keywords]Lupusnephritis;IntegratedtreatmentofTCMwithwesternme

8、dicine狼疮肾炎(lupusnephritis，LN)是系统性红斑狼疮(SLE)最常见的临床表现。2002-12-2006-12，我们采用益肾活血方配合激素和环磷酰胺(CTX)治疗LN30