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1、两种方案治疗晚期胃癌临床对照探究［摘要］目的比较伊立替康联合替吉奥(S-1)与单纯S-1两种不同方案治疗晩期胃癌的疗效及不良反应。方法回顾性分析2009年3月〜2011年7月于我院治疗的晚期胃癌患者65例，采用伊立替康联合S-1治疗的30例为试验组，采用S-1治疗的35例患者为对照组。结果试验组和对照组有效率分别为43.33%和14.29%,差异有统计学意义(P=0.006)□中位疾病进展时间分别为4.5个月和3.0个月，差异有统计学意义(P=0.041)o中位总生存期分别为7.5个月和6.5个月，差异无统计学意义(P>0.05)o不良反
2、应：试验组出现普遍，均可控制，对照组不良反应轻微，试验组和对照组III/IV腹泻分别为13.33%和2.86%,差异有统计学意义(P二0)oIII/IV度中性粒细胞减少分别为13.33%和2.86%,差异有统计学意义(P=0)o结论伊立替康联合S-1疗效肯定、应用方便、耐受性较好，一、二线化疗均适合。对不能耐受两药联合化疗的病例，单药S-1仅推荐一线治疗。［关键词］胃肿瘤；替吉奧；伊立替康；化学治疗；对照研究［中图分类号］R735.2［文献标识码］A［文章编号］1673-7210(2012)01(b)-028-04Cliniccontro
3、lstudyoftworegimensforadvancedgastriccancerLAILinningMAXiaonanDUMinZHUYanhuaDUHuakunDepartmentofOncology,DalianCenterHospital,LiaoningProvince,Dalian116011,China[Abstroct]ObjectiveTocomparethecurativeeffectandthetoxicityoftheregimenofS~1combinedwithirinotecan,andS~1foradv
4、ancedgastriecancer.MethodsPatientswithadvancedgastriccancertotreatinourhospitalformMarch2009toJuly2011wereanalyzedretrospectively,anddividedintoexperimentgroupandcontrolgroup,patientsinexperimentgroupwerereceivedtheregimenofS~1combinedwithirinotecan.Patientsincontrolgroup
5、weretreatedwithS—l.ResuItsEffectiveratewere43.33%and14.29%inexperimentgroupandcontrolgrouprespectively,therewerestatisticdifferencebetweentwogroups(P=0.006).ThemedianTTPinexperimentgroupandcontrolgroupwere4.5monthsand3.0monthsrespectively,therewasastatisticdifferencebetwe
6、entwogroups(P=0.041).ThemedianOSinexperimentgroupandcontrolgroupwere7.5monthsand6.5monthsrespectively,thedifferenceintwogroupswasnotstatisticallysignificant(P>0.05).Adverseeffectsofexperimentgroupweregenerally,allcouldbecontrolled,Adverseeffectsofcontrolgroupweregently.3/
7、4diarrheawere13.33%and2.86%inexperimentgroupandcontrolgrouprespectively,therewasastatisticdifferencebetweentwogroups(P=0).3/4neutropeniawere13.33%and2.86%inexperimentgroupandcontrolgrouprespectively,therewasastatisticdifferencebetweentwogroups(P二0).ConclusionSTcombinedwit
8、hirinotecanisconvenient,safeandpromisingforthepatientswithadvaneedgastriccancer・Theregimeisworth
