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1、导痰汤对大鼠非酒精性脂肪性肝炎治疗作作者：应豪陈汉诚李凌周文红【摘要】目的观察导痰汤对实验性大鼠非酒精性脂肪性肝炎(NASH)的影响，并探讨其作用机理。方法采用高脂饮食复制大鼠NASH模型，以导痰汤低、中、高剂量分别进行干预，然后观察动物一般情况，计算肝指数，观察肝组织脂肪变性及炎症活动度，并查血清学指标ALT、甘油三脂(TG)、总胆固醇(TCH)、高密度脂蛋白(HCL-C)、低密度脂蛋白(LDL-C).肿瘤坏死因子-a(TNF-a),肝组织超氧化物歧化酶(SOD)、丙二醛(MDA)。结果与空白模
2、型组相比，各剂量治疗组大鼠肝指数明显降低(P<；O.05),血清ALT及TG、TCH、LDL-C也有显著降低(P<；O.01〜P<；O.05),但HCL-C无明显变化(P>；0.05),能够升高肝组织SOD活性(P<；O.01〜P<；0.05),降低MDA含量(P<；O.05),血清TNF-a含量显著减少(P<；O.01),且表现出一定的量效关系。各治疗组大鼠肝脏炎症活动度也显著改善(P<；O.05),但量效关系不明显。结论导痰汤有明显防治NASH作用，其机制在
3、于减轻脂类在肝脏的积聚，缓解氧化应激，降低炎症反应，保护肝细胞等作用有关。【关键词】非酒精性脂肪性肝炎大鼠导痰汤动物实验[Abstract】ObjectiveToobservetheinfluenceofDaotandecoctiononnonalcoholicsteatohepatitis(NASH)inrats,andstudytheirrelativemechanisms・MethodsAfterNASHinratswasinducedbyhighfatdiet,theratsofthera
4、peuticgroupsweretreatedwithsmall、middleandhighdoseDaotandecoctionrespectively.Thentheirgeneralconditionwasobserved>liverindexwascomputed,andfattydegenerationandinflammatoryactivityofliverwereobserved.TheALT、triglyceride(TG),totaicholesterol(TCH),lowde
5、nsitylipoprotein(HCL~C),highdensitylipoprotei(LDL-C),TNF-aweredeterminedrespectively.TheSOD,MDAinliverweredeterminedtoo.ResuItsTheliverindexoftherapeuticgroupsweremarkedlyreducedrespectivelycomparedwiththoseofmodelgroup(P<；0.05).ALT,TG,TCHandLDL-Cwe
6、remarkedlyreducedtoo(P<；0.01〜P<；0.05).ButHCL-Coftherapeuticgroupswerenotsignificantdifferentfromthatofmodelgroups(P>；0.05)・TheactivitiesofSODinliverwereelevatedandthecontentlevelofMDAinliverwasdecreasedinalltherapeuticgroups(P<；0.01〜P<；0.05)
7、・thecontentofTNF-ainseruminalltherapeuticgroupsshowedsignificantlydecreasebycomparisonwithmodelgroup(P&It；0.01),andthereweresignificantrelationsofquantityandeffect.Theinflammationofliveroftherapeuticgroupswereimprovedbetterthanthoseinmodelgrouptoo(P&l
8、t；0.05),buttherewerenotsignificantrelationsofquantityandeffect・ConclusionDaotandecoctionhasshowndefiniteeffectonNASH.Thepossiblemechanismisitseffectofalleviationoffataccumulation、lipidantioxidation,anti-inflammationandhepatocyteprotection.[Key
