内科学内分泌总论-高鑫

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1、高鑫GaoXinDepartmentofEndocrinologyZhongshanHospital,FudanUniversityGao.xin@zs-hospital.sh.cnPrinciplesofEndocrinology1Threestagesofendocrinologydevelopment内分泌学发展三阶段腺体内分泌学OrganicEndocrinology组织内分泌学HistologicalEndocrinology分子内分泌学MoleculerEndocrinology2PrinciplesofEndocrinologyBasicofen

2、docrinology______StructureandfunctionofEndocrinologySystem1.Endocrineglandsandcells2.Hormonesecretioncell3.Definitionofhormone:classificationSynthesisandEliminationDiurnalrhythmsVariation4.Correlationwithneuralandimmunesystem5.RegulationofendocrinesystemsAxisragulationRegulationbetw

3、eenhormones6.MechanismsofHormoneActionHormoneswithCellSurfaceReceptors:4typesHormoneswithIntracellularReceptorsDownstreamSignalingPathways7.NutrimentmetabolismClinicalendocrinologyCharacteristicofendocrinesystems:PrinciplesofDiagnosis:Function,Localization,PathologicaldiagnosisPrinc

4、iplesofpreventionandtreatment3PrinciplesofEndocrinology一、内分泌学基础-----内分泌系统结构与功能一、内分泌腺和激素分泌细胞二、激素分泌细胞的结构特点三、激素定义：分类激素的合成与贮存激素分泌方式激素转运激素降解与转换激素的分泌节律血浆激素组分的不均一性激素合成与分泌的调节途径激素与神经系统及免疫系统的相互联系四、内分泌调节轴与调节系统内分泌调节轴激素间的相互调节与影响五、激素作用机制主要作用于核转录因子的激素主要与靶细胞表面受体结合的激素：激素-膜受体相互作用；膜受体结构：一般将膜受体分为四类激素信号

5、的受体后转导通路六、营养素代谢二、临床内分泌内分泌系统疾病特点：诊断原则：诊断包括功能诊断、定位诊断诊断和病因诊断（解剖诊断）治疗原则治原则：4PrinciplesofEndocrinologyBasicofendocrinology______StructureandfunctionofEndocrinologySystem1.Endocrineglandsandcells2.Hormonesecretioncell3.Definitionofhormone:classificationSynthesisandEliminationDiurnalrhythm

6、sVariation4.Correlationwithneuralandimmunesystem5.RegulationofendocrinesystemsAxisragulationRegulationbetweenhormones6.MechanismsofHormoneActionHormoneswithCellSurfaceReceptors:4typesHormoneswithIntracellularReceptorsDownstreamSignalingPathways7.NutrimentmetabolismClinicalendocrinol

7、ogyCharacteristicofendocrinesystems:PrinciplesofDiagnosis:Function,Localization,PathologicaldiagnosisPrinciplesofpreventionandtreatment5EndocrineSystemEndocrineglandsHormonesandtheirregulationsystemMetabolicProcess代谢过程OrgansFunction器官功能Growthanddevelopment生长发育Reproductionandaging生殖衰

8、老Diffusednerveanden