吡嗪酰胺致严重高尿酸血症78例临床分析_吴同柱

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1、ᔉᕠ᳿ςᇁ࿸ᇗۚ୕ූ࿓ᆡ78২ਢԵٳ༅ď໱๝ᇸč໳໳đྏᇏᇍࣷਏ൧၄430064Ďᇏ๭щᅣ໓C઒ᆽѓང໓52Rোٳ1001-0408č2012Ď28-2670-03DOI10.6039/j.issn.1001-0408.2012.28.31ᅋေଢğฐษᔉᕠ᳿ςᇁ࿸ᇗۚ୕ූ࿓ᆡ႕ཙၹ෍ࠣؓॆࢲނᇍਏ႕ཙbٚمğؓ໡ჽ78২ၹႋႨᔉᕠ᳿ςᇁ࿸ᇗۚ୕ූ࿓ᆡߑᆀđՖྟљa୍ਭaุᇗaѩᆡaႨူ࠴ਈaԛགྷ࿸ᇗۚ୕ූ࿓ᆡൈࡗ6۱ٚ૫ࣉྛٳ༅bࢲݔğᔉᕠ᳿ςᇁ࿸ᇗۚ୕ූ࿓ᆡॖିၹ෍ᇏğଳྟa୍ਭնႿ60ෟᆀaุᇗᆷඔ≥28aކѩบ୕Ѩࠇۚ࿓࿢ᆀၞԛགྷ࿸ᇗۚ୕ූ࿓ᆡđაؓᅶቆбࢠ

2、đҵၳႵ๤࠹࿐ၩၬčP＜0.05ĎĠႨူ2ᇛުԛགྷۚ୕ූ࿓ᆡࠫੱᄹնčູ80ĊĎbෙಖ࿸ᇗۚ୕ූ࿓ᆡളੱࢠۚđ֌ᄝਢԵᇍਏᇏն؟ඔ҂ླေ๔ူbࢲંğႋႨᔉᕠ᳿ςุᇗ٧஗a୍ਭொնଳྟߑᆀࠣކѩบ୕Ѩaۚ࿓࿢ߑᆀđԛགྷ࿸ᇗᆡ࿓ූ୕ۚᇗ࿸ၩᇿ్ૡႋൈႷቐᇛ2ူႨᄝԵਢbۚੱളᆡ࿓ූ୕ۚളbܱ࡯Սᔉᕠ᳿ςĠۚ୕ූ࿓ᆡĠ٧஗ClinicalAnalysisofCasesofPyrazineAmide-inducedSeriousHyperuricemiaWUTong-zhučWuhanMedicalTreatmentCenterđWuhan430064đChinaĎA

3、BSTRACTOBJECTIVEğToinvestigatetheinfluentialfactorsofpyrazineamide-inducedserioushyperuricemiaandtheeffectofitonanti-tuberculosistreatment.METHODSğ78patientswithpyrazineamide-inducedserioushyperuricemiainourhospitalwereanalyzedfromgenderđageđbodyweightđcomplicationsđdrugdosageđthetime

4、ofserioushyperuricemiaappearing.RE-SULTSğPyrazineamide-inducedserioushyperuricemiawasrelatedwithfollowingfactorsğmenđolderthan60yearsoldđbodymassindex≥28đhypertensivepatientswithdiabetessufferedfromhyperuricemiaeasilyđcomparedwithcontrolgroupčP＜0.05ĎĠtheincidenceofhyperuricemiaincreas

5、edafter2weeksoftreatmentč80ĊĎ.Althoughtheincidenceofhyperuricemiawasinhighlevelđbutlittlecaseneedtostoptakingdrugintheclinicaltreatment.CONCLUSIONğObeseoldermalehypertensivepatientswithdiabetesmellitusshowshighincidenceofserioushyperuricemia.Greatimportanceshouldbeattachedtotheoccurre

6、nceofserioushyperuricemiawithin2weeks.KEYWORDSPyrazineamideĠHyperuricemiaĠObeseᔉᕠ᳿ςቔູᇍਏࢲނѨӈႨူ໾ᆭ၂đᄝࢲނѨ.၂Ϯሧਘ఼߄ᇍਏࢨ؍ఏሢ٤ӈᇗေቔႨđۚ୕ූ࿓ᆡ൞ఃቋӈ࡮ܴҳቆଳྟ50২č64ĊĎđ୯ྟ28২č36ĊĎđ୍ਭ18～78ڬቔႨđ౞aᇏ࿓୕ූᄹۚࣜؓᆡԩ৘ުؓದุ҂߶Ӂളෟđ௜न୍ਭ45.7ෟđఃᇏ60ෟၛഈ25২č32ĊĎĠ࿓୕ූ҂ਅ႕ཙđ࿸ᇗۚ୕ූ࿓ᆡॖିᇁܱࢫကaႺྏ࿓ܵࠥ832～1960μmol·L－1bؓᅶቆଳྟ26২č33.3ĊĎđ୯ྟ52২Ѩb

7、ູฐษᔉᕠ᳿ςႄఏ࿸ᇗۚ୕ූ࿓ᆡ႕ཙၹ෍ࠣؓॆč66.7ĊĎđ௜न୍ਭ40.1ෟđ60ෟၛഈ13২č17ĊĎĠ࿓୕ූࢲނᇍਏ႕ཙđгᆀؓ໡ჽၹᔉᕠ᳿ςᇁ࿸ᇗۚ୕ූ࿓142～416μmol·L－1bᆡ78২ߑᆀਢԵሧਘࣉྛٳ༅b78২ܴҳቆߑᆀᇏุᇗᆷඔčBMIĎ≥28ᆀ19২ሧਘაٚمč24.3ĊĎđކѩบ୕Ѩ17২č21.8ĊĎđۚ࿓࿢15২č19.2ĊĎb.ବೆაஆԢѓሙؓᅶቆᇏBMI≥28ᆀ8২č10.2ĊĎđކѩบ୕Ѩ7২č8.9ĊĎđ෮Ⴕߑᆀनটሱ໡ჽ2008－2010୍ࡗᇾჽߑᆀđࢲނۚ࿓࿢3২č3.8ĊĎbѨᆐ؎ૼಒđᇍਏ௹ࡗҐႨݣᔉᕠ᳿ςॆ᭲

8、ٚσđԛགྷ