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1、冠心病介入治疗的热点-2008中国医学科学院阜外心血管病医院高润霖DES的安全性和长期疗效 新一代DESFromTCT2006FromTCT2006TimeafterInitialProcedure(years)01234TimeafterInitialProcedure(years)TAXUSI,II,IV,V,VI(n=3,513)RAVEL,SIRIUS,E-SIRIUS,andC-SIRIUS(n=1,748)CYPHERstent(n=870)Baremetalstent(n=878)StoneGWetal.NEJM2007;356:998-10080
2、1234TAXUSstent(n=1,755)Baremetalstent(n=1,758)9Prospective,Double-Blind,RandomizedTrialsFreedomFrom(Protocol)StentThrombosisP=0.2099.4%(5)98.8%(10)P=0.3099.1%(14)98.7%(20)TimeafterInitialProcedure(years)01234TimeafterInitialProcedure(years)TAXUSI,II,IV,V,VI(n=3,513)RAVEL,SIRIUS,E-SIRI
3、US,andC-SIRIUS(n=1,748)CYPHERstent(n=870)Baremetalstent(n=878)StoneGWetal.NEJM2007;356:998-100801234TAXUSstent(n=1,755)Baremetalstent(n=1,758)9Prospective,Double-Blind,RandomizedTrialsFreedomFrom(Protocol)StentThrombosisP=0.2099.4%(5)98.8%(10)P=0.3099.1%(14)98.7%(20)5vs.0,P=0.025After
4、1year9vs.2,P=0.028After1yearTimeafterInitialProcedure(years)01234TimeafterInitialProcedure(years)TAXUSI,II,IV,V,VI(n=3,513)RAVEL,SIRIUS,E-SIRIUS,C-SIRIUS(n=1,748)P=0.2394.7%(45)93.3%(57)CYPHERstent(n=870)Baremetalstent(n=878)StoneGWetal.NEJM2007;356:998-100801234P=0.6893.4%(92)93.9%(8
5、6)TAXUSstent(n=1,755)Baremetalstent(n=1,758)9Prospective,Double-Blind,RandomizedTrialsFreedomFromAllCauseDeathTimeafterInitialProcedure(years)01234TimeafterInitialProcedure(years)TAXUSI,II,IV,V,VI(n=3,513)RAVEL,SIRIUS,E-SIRIUS,C-SIRIUS(n=1,748)P=0.8693.8%(53)93.6%(55)CYPHERstent(n=870
6、)Baremetalstent(n=878)StoneGWetal.NEJM2007;356:998-100801234P=0.6693.7%(105)93.0%(115)TAXUSstent(n=1,718)Baremetalstent(n=1,727)9Prospective,Double-Blind,RandomizedTrialsFreedomFromMyocardialInfarctionTimeafterInitialProcedure(years)01234TimeafterInitialProcedure(years)TAXUSI,II,IV,V,
7、VI(n=3,513)RAVEL,SIRIUS,E-SIRIUS,C-SIRIUS(n=1,748)P<0.000176.4%(202)92.2%(66)CYPHERstent(n=870)Baremetalstent(n=878)StoneGWetal.NEJM2007;356:998-100801234P<0.000180.0%(338)89.9%(166)TAXUSstent(n=1,755)Baremetalstent(n=1,758)9Prospective,Double-Blind,RandomizedTrialsFreedomFromIschemic
8、TLRAR
