心肌病的分类（英文）-课件，幻灯，PPT

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1、The4thChina-JapanCardiovascularForumNewClassificationsofCardiomyopathiesAkiraMatsumori,MD,PhD,FACC,FAHA,FESCPresident,InternationalSocietyofCardiomyopathiesandHeartFailureSecretary,WorldHeartFederationChairman,ScientificAdvisoryBoard&Treasurer,APSCKy

2、otoUniversityGraduateSchoolofMedicineKyoto,JapanOctober23,2008,BeijingNormalDilatedHypertrophicRestrictiveArrhythmogenicRightVentricularSystoleDiastoleClassificationofCardiomyopathiesPrimaryCardiomyopathies(predominantlyinvolvingtheheart)GeneticMixed

3、*AcquiredHCMARVC/DLVNCConductionDefectsMitochondrialmyopathiesDCMRestrictive(non-hypertrophiedandnon-dilated)Inflammatory(myocarditis)Stress-provoked（”tako-tsubo”）PeripartumTachycardia-inducedInfantsofinsulin-dependentDiabeticmothersCirculation2006;1

4、13:1807-1816IonChannelDisordersLQTSBrugadaSQTSCPVTAsianSUNDS*PredominantlynongeneticPRKAG2DanonGlycogenStorageSecondaryCardiomyopathiesInfiltrativeStorageToxicityEndomyocardialInflammatory(granulomatous)EndocrineCardiofacialNeuromuscular/neurological

5、NutritionaldeficiencyAutoimmune/collagenElectrolyteimbalanceConsequenceofCancertherapyCirculation2006;113:1807-1816GeneMutationsAssociatedwithMultiplePhenotypesofCardiomyopathies-MyosinheavychainCardiactroponinT-TropomyosinCardiacmyosinbindingProte

6、inCCardiactroponinIActinTitinDesminMuscleLIMproteinTelethoninDesmoplakinPlakoglobinGenePhenotypesHCMDCMRCMARVC/DSarcomereproteinsZ-discproteinDesmosomeproteinIntermediatefilamentsHypertrophicCardiomyopathy・Abouthalfofcasesshowfamilialoccurrence.・Abou

7、thalfoffamilialHCMhavegenemutationsofsarcomereproteins(~25%oftotalHCM).・Specific(Secondary)cardiomyopathiesoftenshowHCMphenotype.Storage:Fabry’sdiseaseInflammatory:SarcoidosisHCVcardiomyopathyCoxsackieBvirusAdenovirusHepatitisCvirusDilatedCardiomyopa

8、thyMyocarditisViralInfectionandPhenotypesofCardiomyopathiesCirculation1995;92:2519-2525BiochemBiophysResCommun1996;222:678-682LabInv.2000;80:1137-1142HypertrophicCardiomyopathyViralInfectionoftheHeartDiffuseCHF/DCMSystolicHFRegionalAneurysmSubendocar