心衰中的炎症-课件，幻灯，PPT(英文）

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1、1InflammationinheartfailureLiaoYu-HuaInstituteofCardiologyUnionHospitalHuazhongUniversityofScienceandTechnology,WuhanChina2CognitiveprocessofpathophysiologyandtherapyinhaertfailureFluidretentionHemodynamicabnormityNeurohormoneabnormityCytokines40-60era70-8

2、0era80-90era90eraNeurohormoneantagonistExpandvessel/cardiotonicDiuretic？3InflammationandHeartfailureInteractionbetweenneuroendocrineandcytokinesinheartfailuretherapybetweeninflammationandheartfailure4β-adrenergicstimulationinducesproinflammatorycytokineexp

3、ressioninmyocardiummRNAexpressionbyNorthernblottingproteinlevelsbyWesternblotting*P<0.01,**P<0.0001vssaline-treatedanimals.Murrayetal.Circulation.2000;101:2338-2341.Incontrolmyocardium,TNF-a,IL-1bandIL-6werenotdetected.Isoproterenolinfusionsignificantlyinc

4、reasedexpressionofall3cytokines,indicatingthatchronicβ-adrenergicstimulationwasassociatedwithproinflammatorycytokineexpression.5CausalrelationshipbetweenAngIIandTGF-β1incardiachypertrophySchultzJEJ,etal.JClinInvest2002;109:787–96ThelackoftheTGFβ1genefullyp

5、reventedthedevelopmentofcardiachypertrophyinducedbysubpressordosesofAngIIthatwasobservedinwildtypemiceAngII-inducedcardiachypertrophyismediatedbyTGF-β16EvidenceforaconnectionbetweenAngIIandTGF-β1incardiactissueStephanRosenkranz.CardiovascularResearch2004;6

6、3:423–432SomestudiesindicatethatAngIIandTGF-β1actinanauto-/paracrinemanner,andsuggestcross-talkbetweenthevariousmyocardialcelltypesandcompartments7AngiotensinII-inducedmyocardialTNFbiosynthesisintheadultheartTNFmRNAexpressionKalraD,etal.Circulation2002;105

7、:2198–205.TreatmentwithAngIIresultedinarapidincreaseinTNFmRNAsynthesisinisolatedbufferperfusedhearts8AngiotensinIIinducedactivationofNF-ĸBKalraD,etal.Circulation2002;105:2198–205.StimulationwithAngIIleadtoarapidincreaseinNF-κBbindingactivityinisolatedbuffe

8、rperfusedhearts,thefindingsuggestapossiblepathwayinAngIImediatedTNFbiosynthesis9Cross-regulationbetweentherenin-angiotensinsystemandinflammatorymediatorsK.Sekiguchietal.CardiovascularResearch2004；63：433–442T