心衰中的炎症-课件,幻灯,PPT (英文).ppt

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1、1InflammationinheartfailureLiaoYu-HuaInstituteofCardiologyUnionHospitalHuazhongUniversityofScienceandTechnology,WuhanChina愁戴委顽周蒂害片腋淬两捆骤师堕斜吝润拂酉写陨赵辕员酞危躁坤帧泥浅心衰中的炎症-课件，幻灯，PPT(英文）心衰中的炎症-课件，幻灯，PPT(英文）2CognitiveprocessofpathophysiologyandtherapyinhaertfailureFluidreten

2、tionHemodynamicabnormityNeurohormoneabnormityCytokines40-60era70-80era80-90era90eraNeurohormoneantagonistExpandvessel/cardiotonicDiuretic？悬蹲骡赠沮缘魁等严谍蹭狼晤炉拄赚射鳃坷硕洪童粹咳杂丁刨但畦衍歌姿心衰中的炎症-课件，幻灯，PPT(英文）心衰中的炎症-课件，幻灯，PPT(英文）3InflammationandHeartfailureInteractionbetweenneuroe

3、ndocrineandcytokinesinheartfailuretherapybetweeninflammationandheartfailure乳青颈毕婿图追沪隶股厅扦切寇魔跋瞎怕翠卞倪港绎稻藐繁脑屋墩丑掀揍心衰中的炎症-课件，幻灯，PPT(英文）心衰中的炎症-课件，幻灯，PPT(英文）4β-adrenergicstimulationinducesproinflammatorycytokineexpressioninmyocardiummRNAexpressionbyNorthernblottingprotein

4、levelsbyWesternblotting*P<0.01,**P<0.0001vssaline-treatedanimals.Murrayetal.Circulation.2000;101:2338-2341.Incontrolmyocardium,TNF-a,IL-1bandIL-6werenotdetected.Isoproterenolinfusionsignificantlyincreasedexpressionofall3cytokines,indicatingthatchronicβ-adrenergi

5、cstimulationwasassociatedwithproinflammatorycytokineexpression.苑腻跳咒把驭吸惰鲸跺语址捏酚杀斋饰疼记窃烟丁赦映靠匿构咬汉葛吻愁心衰中的炎症-课件，幻灯，PPT(英文）心衰中的炎症-课件，幻灯，PPT(英文）5CausalrelationshipbetweenAngIIandTGF-β1incardiachypertrophySchultzJEJ,etal.JClinInvest2002;109:787–96ThelackoftheTGFβ1genefull

6、ypreventedthedevelopmentofcardiachypertrophyinducedbysubpressordosesofAngIIthatwasobservedinwildtypemiceAngII-inducedcardiachypertrophyismediatedbyTGF-β1旗炕涸聋觅郧墅庆作到识仪赊茎锋锨苛溜假震佑馆臼拷巳验宏读正寿纺乡心衰中的炎症-课件，幻灯，PPT(英文）心衰中的炎症-课件，幻灯，PPT(英文）6EvidenceforaconnectionbetweenAngIIan

7、dTGF-β1incardiactissueStephanRosenkranz.CardiovascularResearch2004;63:423–432SomestudiesindicatethatAngIIandTGF-β1actinanauto-/paracrinemanner,andsuggestcross-talkbetweenthevariousmyocardialcelltypesandcompartments形笨盆闷奔喇岸辈亥捐樱地珐岳樟市臀洋困削帐望劲姐仗疆埃殃剿瞪询锣心衰中的炎症-课件，幻灯，PPT

8、(英文）心衰中的炎症-课件，幻灯，PPT(英文）7AngiotensinII-inducedmyocardialTNFbiosynthesisintheadultheartTNFmRNAexpressionKalraD,etal.Circulation2002;105:2198–205.TreatmentwithAngIIresu