资源描述：
《泮托拉唑治疗反流性食管炎疗效观察》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、泮托拉卩坐治疗反流性食管炎疗效观察［摘耍］冃的：评价并与奥美拉陀比较泮托拉陀治疗反流性食管炎的疗效和安全性。方法：60例胃镜诊断的反流性食管炎患者，随机分为2纟R,每天分别口服泮托拉I姓胶囊40mg和奥美拉哇肠溶片40mg,于治疗4周和8周后观察反酸、烧心、反食等症状的改善情况，并复查胃镜，观察镜下治愈率，详细记录不良反应。结果：治疗4周后，两组症状明显改善,症状记分较治疗前明显下降(P<0.01)o治疗4周、8周后，泮托拉卩坐组症状改善总有效率分别为83.3%、93.3%,对照组为76.7%、86
2、.7%,两组比较无显著性差异(P>0.05)；泮托拉哇组治愈率分别为60.0%、83.3%,奥美拉畔组为53.3%、76.7%,两组比较无显著性差异(P>0.05)o两组患者均能良好耐受，末发现严重的不良反应。不良反应率泮托拉哇组为3.3%,奥美拉哮组为6.7%,两组比较无显著性差界(P>0.05)。结论：泮托拉呼是治疗反流性食管炎安全、有效的笏物。［关键词］胃食管反流病；反流性食管炎；泮托拉醴；药物治疗［中图分类号］R571［文献标识码］A［文章编号］1673-7210(2007)08(a)-04
3、2-02TheeffectsofpantoprazoleinpatientswithrefluxesophagitisCHENQi-ming,LONGJie-wen,YANGZhi-fen(TheSecondPeople"sHospitalofZhaoqing,Zhaoqing526060,China)［Abstract］objective：Tocomparetheefficacyandsafetyofpantoprazolowiththatofomeprazoleinpatientswithref
4、luxesophagitisdisease・Methods：60patientswithendoscopicallyconfinnedrefluxesophagitiswereenrolled.Theywererandomlydividedintotwogroups.30patientsweretreatedwithaonce-dailydoseofpantoprazole40mginthetreatmentgroups.30patientsweretreatedwithaonce-dailydos
5、eofomcprazole40mginthecontrolgroup,andrefluxsymptomsincludingregurgitation,heartburnandfoodrefluxwereevaluatedafter4and8weeks・Andendoscopywasperformedtostudythehealingrate.Results：After4weekstreatment,thesymptomsimprovedsignificantly,andsymptomscoreswe
6、regreatlydecreasedinbothgroups(P<0・01)•Thetotaleffectiverateofsymptomimprovementwas83.3%,93.3%after4,8weeksinlhetreatmentgroups,and76・7%，86.7%inthecontrolgroup.Therewasnodifferencebetweentwogroups(P>0.05).Thehealingratewas60.0%,83.3%after4,8weeksinthet
7、reatmentgroup,and53.3%,76.7%inthecontrolgroup.Therewasnodifferencebetweentwogroups(P>0-05),Therateofsideeffectswere3.3%inthetreatmentgroup,6・7%inthecontrolgroup.Therewasnodifferencebetweentwogroups(P>0・05)・Conclusion：Pantoprazoleisaneffectiveandsafedru
8、gforrefluxesophagitis.［Keywords］Gastroesophagealrefluxdisease；Refluxesophagitis；Pantoprazole；Drugtherapy胃食管反流疾病是消化系统常见病。反流性食管炎有效的治疗是减少胃酸分泌，泮托拉醴作为新一代质子泵阻滞剂，在治疗酸相关性消化系统疾病方面有良好的疗效［1］。2001年11月~2003年11月,本院应用泮托拉哇治疗30例反流性食管炎患者,并用奥米拉哇治疗30例作为对照组
