医生晋升职称所需肿瘤类优秀论文 (34)

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1、含亚砷酸方案介入治疗中晚期肝癌的疗效评价作者：谢艳茹周月芬应筱莉作者单位：323000浙江省丽水市中心医院肿瘤内科【摘要】目的评价亚砷酸联合化疗药物及超液化碘油行肝动脉化疗栓塞术（TACE）治疗中晚期肝癌的疗效和不良反应。方法中晚期肝癌共65例随机分2组，A组32例行肝动脉灌注羟基喜树碱20mg或阿霉素50mg、顺铂60mg、超液化碘油5～20ml，B组33例在上述化疗药基础上加用亚砷酸20mg。观察其疗效与不良反应。结果A组客观有效率（CR+PR）达43.8%（14/32），获益率（CR+PR+NC）达71.2%（23/32）；B组客观有效率

2、达51.1％(17/33)，获益率为93.9%（31/33），两组客观有效率比较无显著性差异（P＞0.05），获益率比较有显著性差异（P<0.05）。患者血清AFP水平，A、B组治疗前后比较有非常显著性差异，A、B组治疗后比较有显著性差异。不良反应主要为骨髓抑制、恶心呕吐、疼痛、发热，两组均无Ⅳ度不良反应,无治疗相关性死亡。结论亚砷酸联合化疗药及超液化碘油行TACE治疗中晚期肝癌有较好疗效，不良反应较小，是肝癌介入治疗用药的较佳选择，值得临床推广。【关键词】亚砷酸/三氧化二砷介入治疗原发性肝癌　　【Abstract】ObjectiveToeva

3、luatetheeffectandtoxicityofarsenictrioxidecombinedwithchemotherapydrugandlipoidol-ultrafliudinthetreatmentofmiddle-latehepatocarcinomabytranscatheterarterialchemoembolization（TACE）.Methods65patientswithmiddle-latehepatocarcinomaweredividedintotwogroupsatrandom.HCPT20mgorDoxo

4、rubicin50mg,Cisplatin60mgandlipoidol-ultrafliud5-20mlwereinjectedintohepaticarterybycathetersin32patientsofAgroup;basedonthemedicineusedingroupA,20mgofArsenictrioxidewasaddedin33patientsofBgroup.Theeffectandtoxicitywereobserved.ResultsTheobjectiveresponserateofAgroupwas43.8%

5、（14/32），theclinicalbeneficialresponserate(CR+PR+SD)was71.2%（23/32）；TheobjectiveresponserateofBgroupwas51.1％(17/33)，theclinicalbeneficialresponserate(CR+PR+SD)was93.9%（31/33）,thedifferenceofobjectiveresponserateintwogroupswasnotsignificant（P＞0.05）,butthedifferenceofclinicalbe

6、neficialresponseratewassignificant.TheleverofAFPwasverysignificanlyloweredinbothgroupsaftertreatmentcomparedwiththatbeforetreatment,itwasalsosignificantlydifferentfromgroupAtogroupBaftertreatment.Majoradverseeffectsweremildbonemarrowdepression、nauseaandvomiting、pain、pyrexiaa

7、ndhepaticdamage,buttherewerenotⅣdegreetoxicresponsenordeathrelatedtotreatment.ConclusionArsenictrioxidecombinedwithchemotherapydrugandlipoidol-ultrafliudinthetreatmentofmiddle-latehepatocarcinomabyTACEiseffectiveandhaslessadverseeffect,whichisabetterchoiceforhepatocarcinomai

8、nterventionaltherapy.　　【KeyWords】As2O3/ArsenictrioxideInterventionaltherapy