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ID:42827494
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页数:4页
时间:2019-09-22
《医生晋升职称所需肿瘤类优秀论文 (34)》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、含亚砷酸方案介入治疗中晚期肝癌的疗效评价作者:谢艳茹周月芬应筱莉作者单位:323000浙江省丽水市中心医院肿瘤内科【摘要】目的评价亚砷酸联合化疗药物及超液化碘油行肝动脉化疗栓塞术(TACE)治疗中晚期肝癌的疗效和不良反应。方法中晚期肝癌共65例随机分2组,A组32例行肝动脉灌注羟基喜树碱20mg或阿霉素50mg、顺铂60mg、超液化碘油5~20ml,B组33例在上述化疗药基础上加用亚砷酸20mg。观察其疗效与不良反应。结果A组客观有效率(CR+PR)达43.8%(14/32),获益率(CR+PR+NC)达71.2%(23/32);B组客观有效率
2、达51.1%(17/33),获益率为93.9%(31/33),两组客观有效率比较无显著性差异(P>0.05),获益率比较有显著性差异(P<0.05)。患者血清AFP水平,A、B组治疗前后比较有非常显著性差异,A、B组治疗后比较有显著性差异。不良反应主要为骨髓抑制、恶心呕吐、疼痛、发热,两组均无Ⅳ度不良反应,无治疗相关性死亡。结论亚砷酸联合化疗药及超液化碘油行TACE治疗中晚期肝癌有较好疗效,不良反应较小,是肝癌介入治疗用药的较佳选择,值得临床推广。【关键词】亚砷酸/三氧化二砷介入治疗原发性肝癌 【Abstract】ObjectiveToeva
3、luatetheeffectandtoxicityofarsenictrioxidecombinedwithchemotherapydrugandlipoidol-ultrafliudinthetreatmentofmiddle-latehepatocarcinomabytranscatheterarterialchemoembolization(TACE).Methods65patientswithmiddle-latehepatocarcinomaweredividedintotwogroupsatrandom.HCPT20mgorDoxo
4、rubicin50mg,Cisplatin60mgandlipoidol-ultrafliud5-20mlwereinjectedintohepaticarterybycathetersin32patientsofAgroup;basedonthemedicineusedingroupA,20mgofArsenictrioxidewasaddedin33patientsofBgroup.Theeffectandtoxicitywereobserved.ResultsTheobjectiveresponserateofAgroupwas43.8%
5、(14/32),theclinicalbeneficialresponserate(CR+PR+SD)was71.2%(23/32);TheobjectiveresponserateofBgroupwas51.1%(17/33),theclinicalbeneficialresponserate(CR+PR+SD)was93.9%(31/33),thedifferenceofobjectiveresponserateintwogroupswasnotsignificant(P>0.05),butthedifferenceofclinicalbe
6、neficialresponseratewassignificant.TheleverofAFPwasverysignificanlyloweredinbothgroupsaftertreatmentcomparedwiththatbeforetreatment,itwasalsosignificantlydifferentfromgroupAtogroupBaftertreatment.Majoradverseeffectsweremildbonemarrowdepression、nauseaandvomiting、pain、pyrexiaa
7、ndhepaticdamage,buttherewerenotⅣdegreetoxicresponsenordeathrelatedtotreatment.ConclusionArsenictrioxidecombinedwithchemotherapydrugandlipoidol-ultrafliudinthetreatmentofmiddle-latehepatocarcinomabyTACEiseffectiveandhaslessadverseeffect,whichisabetterchoiceforhepatocarcinomai
8、nterventionaltherapy. 【KeyWords】As2O3/ArsenictrioxideInterventionaltherapy
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