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1、青年脑梗死患者血清同型半胱氨酸的表达及意义蒋暉卿，黄杰上海市奉贤区中心医院神经内科上海201499【摘要】：目的：观察青年脑梗死患者血清同型半胱氨酸(Homocysteine,Hey)水平的变化，探讨青年脑梗死患者血清Hey值对脑梗死的影响，为青年脑梗死病人的防治提供临床依据。方法：选取青年脑梗死患者45例，老年脑梗死患者45例，及同吋期健康体检人员45例，检查各组人员空腹血清Hey、高密度脂蛋白(IIDL)、低密度脂蛋白(LDL)、甘油三酯(TG)、胆固醇(TC)水平，检测颈动脉内膜中层厚度(IMT)及斑块情况。结果：青年脑梗死患者血清Hey较老年脑梗死组及健康体检组均明显增高(p
2、均为0.000),HDL.LDL、TG、TC等指标无明显差异(p>0.05),青年脑梗死患者颈动脉中层厚度、不稳定斑块发生率明显高于对照组(p分别为0.028和0.000),与老年脑梗死患者相仿(〃分别为0.247和0.724)O结论：青年脑梗死患者血清Iley较其它各组均明显升高，高同型半胱氨酸可促进颈动脉粥样硬化的进程、加重颈动脉粥样硬化程度，与脑梗死复发关系密切，是青年脑梗死患者的重要危险因素。【关键词】：青年脑梗死；同型半胱氨酸TheexpressionandsignificanceofserumhomocysteineinYouthinfarctionpatientsoJi
3、angWeiQing,huangjie(DepartmentofNeurology,shanghaifengxiancenterhospital,fengxian201499)[Abstract]Objective:ObservethelevelchangesofHomocysteine(Hey)inyouthcerebralinfarctionpatients,anddiscusstheserumHeyofyouthcerebralinfarctionpatientsvalueontheinfluenceofcerebralinfarction,provideclinicalbas
4、isforpreventionandcontrolofyouthcerebralinfarctionpatientsoMethod:Select45Youthinfarctionpatients,45elderlyinfarctionpatients,45healthyphysicalexaminationpersons,checkthelevelsoffastingscrumHcy>triglyceride(TG)、cholesterol(TC)、high-densitylipoprotein(HDL)^lowdensitylipoprotein(LDL)ofeverygroup,
5、testtheintima-mediathickness(IMT)ofcarotidarteryandplaque<>Results:ThelevelofserumHeyinYouthinfarctionpatientsishigherthanelderlyinfarctionpatientsandhealthygroup(p<0.05),nosignificantdifferencebetweenofHDL、LDL、TG、TC(/?>0.05),theintima-mediathickness(IMT)ofcarotidarteryandunstableplaqueofYouthi
6、nfarctionpatientsarcsignificantlyhigherthanthecontrolgroup,andsimilarwiththeelderlyinfarctionpatientsqConclusion:ThelevelofserumHeyinYouthinfarctionpatientsishigherthanothergroups,itcanpromotetheprocessofcarotidatherosclerosis,increasedegreeofcarotidatherosclerosis,closelyassociatedwithrecurren
7、ceofcerebralinfarction,itistheimportantriskfactorsofyouthinfarctionpatientso【keywords】:Youthinfarction;Homocysteine水课题來源：上海市卫牛局科研课题计划任务（编号：20124286）通讯作者：黄杰。E-mail：hjiel970@163.como脑梗死是一种严重威胁人类生命健康的常见疾病，以往好发于老年人。近些年，随着社会的发展，人们生活节奏的
