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1、®世界华人消化杂志2007年7月18日;15(20):2186-2193wcjd@wjgnet.comISSN1009-3079CN14-1260/R基础研究BASICRESEARCHCEBPs及其调节的基因与大鼠肝再生相关性分析王望,陈晓光,徐存拴■背景资料王望,徐存拴,河南师范大学生命科学学院河南省新乡市correlatedwithliverregenerationwereconfirmed肝脏具有很强的453007bycomparisoninatrueandfalseoperation.再生能力,大鼠部陈晓光,河南省科技部共建细胞分化调控重点实验室河南分肝切除模型被省新乡市
2、453007广泛用于研究肝王望,河南师范大学生命科学学院细胞生物学专业在读硕士研RESULTS:Twenty-sevengenescorrelatedwith究生,主要从事肝再生分子机制的研究.再生.肝再生涉通讯作者:徐存拴,453007,河南省新乡市建设东路46号,河南LR,11ofwhichwereup-regulated,6down-reg-及细胞激活、去师范大学生命科学学院.xucs@x263.netulated,and10thatwereup-regulatedatcertain分化、增殖及调电话:0373-3326001timepointsbutdown-regula
3、tedatothers.The控、再分化和组收稿日期:2007-04-24接受日期:2007-05-10织结构功能重建up-regulatedrangewas2to128foldofthecom-等生理生化过程,parisongroup,whilethedown-regulatedrange受到包括转录因CorrelationanalysisofCCAAT/was2to16fold.Thenumberofgenesexpressed子在内的多种因素调控.enhancer-bindingproteinsandintheLRinitiation[0.5-4hoursafterpart
4、ialtheirregulatedgeneswithrathepatectomy(PH)],G0/G1transition(4-6hoursafterPH),cellproliferation(6-66hoursafterliverregenerationPH)andcelldifferentiationandtissuestructurereconstruction(72-168hoursafterPH)stagesWangWang,Xiao-GuangChen,Cun-ShuangXuwere18,3,8and1,respectively.Totalexpres-sionti
5、meswere18,11,25and16,respectively,WangWang,Cun-ShuangXu,LifeScienceCollegeofshowingthatthecorrelatedgeneswereprimar-He’nanNormalUniversity,Xinxiang453007,He’nanProv-ince,ChinailyexpressedintheLRinitiationstage.GenesXiao-GuangChen,KeyLaboratoryofCellDifferentiationwereup-regulated126foldanddow
6、n-regulatedandRegulationCo-constructionfromScienceandTechnol-76fold,indicatingthatmoregeneswereup-ogyDepartmentofHe’nanProvince,Xinxiang453007,He’nanProvince,Chinaregulatedthandown-regulatedinLR.Correspondenceto:Cun-ShuangXu,LifeScienceCol-legeofHe’nanNormalUniversity,46JiansheEastRoad,CONCLU
7、SION:CEBPsandtheirregulatedXinxiang453007,He’nanProvince,China.xucs@x263.netgenesarehighlycorrelatedwithcellprolifera-Received:2007-04-24Accepted:2007-05-10tion,celldifferentiation,cellapoptosis,inflam-mation,stressresponse,lipidsmetabolisman
