氨基酸及其衍生物代谢和运输相关基因在大鼠肝再生中表达模式和作用的分析

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1、耋摹匡圣i薹量量霍妻薹三三薹翼孽萋雪零霎喜薹至耋薹薹薹主季亨董鏊妻耋妻拿薹妻耄堂乏搴羞雾垂囊j萋三罩善摹茎耋妻董耋l羹妻妄妻!塞妻囊塞霉手嘻蕈孽垂耋妻蚕薹

2、誉耄蓄雾枣薹琴季i；宴；萋乏耋i毒l羹亨专r璧攮霪，；；；≤≤莹；主：二；≤；；三；藿毫喜；≤手§蠢圣ExpressionpatternsandactionanalysisofgenesrelatedwiththemetabolismandtransportofaminoacidsandtheirderivantsintheratliverregenerationAbstractAminoacidsandmeirderivantshave

3、impor￡antbiolo西calactions．Therefore，therelationshipoftheliVerregeneration(Uqa11dtlleexpressionactivityofthegenesrelatedwith也emetabolisma11dtransportof锄inoacidsa11dtbe．rderivaIltsShouldbe舢曲erinvestigated．Thisarticleanalyzedthegeneexpressionchangesoftheregenerating1iVersa矗erpartialh印atectomy(PH)andsh

4、啦operation(SO)atrecoVerytimeO．5，1，2，4，6，8，12，16，24，30，36：42，54，66，96a11d144husingtheRatGenome2302．0aIT吼whichcon协ins137genesofessential锄moacidsaIldtheirderivalivemetabolism，77non-essential，aIld46aminoacid咖spon．GencsbothwhichhadsignificaIltexpressionchangeatleastatonetimepoint，andwhichshoweds噜工liflca

5、fltorverysigIlmcalltdi恐rencebetweenPHgroupa1】dSOgroupwereidentifitiedasLR—rela主ed．Amongthem，38，19and13geneswereprimarilycorlnrrnedL艮related．TheinitialeXpressinggenenumbersininitiation(0．5~4hajRerPH)，Go／Gl仃a11sition(4“hafterPH)，cellpmlifcration(6～66h啦erPH)，a11dcellrcdi腩rentiation，stmcturaland劬ctionr

6、econstmctionphase(66～144hafterPH)were52，9，14and2，respcctively，andthecorrespondingtotalexpressinggenenumbers52，42，61a11d46，demonstratingthatLR-relatedgenesprimarilystartedtheirexprcssionintheinitiationphase，alldworkedindi位renIphases．Accordingtotheirexpwssionsimil州饥thesegeneswereclaSsinedimo5typesinc

7、ludingo蝴yup一，predominantlyup一，0111ydo啪一，predoIIlinaIltlydOwn一，a11dup一／down·regulated，involVing42，5，16，4and1genes，respectively；andthetotaltimesoftheirup-anddownvregulatedexpressionwere31landl54，demons虹atingthatexpressionofmostgeneswaseI】llancedinLR，Wllilefewa仕enated．Accordingtotimerelevance，they啪rec

8、lassifiedinto9gr01lpsincludingO．5锄d12h，1aIld4h，2and54h，6h，8aIld96h，16h，24and36h，30and42h，66and144h，andmetotalexpressiongenen嘲berswere36，39，38，27，44，32，4l，38afld41，respectively，demonstratingtllatthecellularp