浙江大学医学免疫学经典课件免疫9、13-B细胞

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1、LieWang(汪洌）浙江省杭州市浙江大学紫金港校区医学院科研楼A810-814医学院免疫学研究所BlymphocytesandHumoralImmuneResponseThediscoveryofBcellimmunity1954-BruceGlick,OhioStateUniversityStudiesonthefunctionofthebursaofFabricius,alymphoidorganinthecloacalregionofthechickenBursawaslaterfoundtobetheo

2、rganinwhichantibodyproducingcellsdeveloped–antibodyproducingcellswerethereaftercalledBcellsMammalsdonothaveabursaofFabriciusTransfermarkedfoetallivercellsOriginofBcellsandorganofBcellmaturationNoMatureBcellsAfterbirth,developmentcontinuesinthebonemarrowNormal

3、bonemarrowDefectivebonemarrowMaturemarkedBcellsinperipheryBcelldevelopmentstartsinthefoetalliverBcelldevelopmentinthebonemarrowBRegulatesconstructionofanantigenreceptorBoneMarrowprovidesaMATURATION&DIFFERENTIATIONMICROENVIRONMENTforBcelldevelopmentEnsureseach

4、cellhasonlyonespecificityBChecksanddisposesofself-reactiveBcellsBExportsusefulcellstotheperipheryBProvidesasiteforantibodyproductionBSecretedFactors-CYTOKINES2.SecretionofcytokinesbystromalcellsBBonemarrowstromalcellsnurturedevelopingBcellsTypesofcytokinesand

5、cell-cellcontactsneededateachstageofdifferentiationaredifferentStromalcell1.Specificcell-cellcontactsbetweenstromalcellsanddevelopingBcellsCell-cellcontactBonemarrowstromalcellMaturingBcellsBBStromalcellBlineagecommitmentHSC(hematopoieticstemcell)MPP(淋巴系髓系多能前

6、体细胞)ELP(earliestlymphocyteprogenitor)ETP(earlyT-lineageprogenitor)CLP(commonlymphoidprogenitor)HSCDevelopmentandmigrationofBcells(Anoverview)StagesofdifferentiationinthebonemarrowaredefinedbyIggenerearrangementBCELLSTAGEIgHGENECONFIGURATIONStemcellEarlypro-BL

7、atepro-BLargepre-BGermlineDHtoJHVHtoDHJHVHDHJHPre-BcellreceptorexpressedIglightchaingenehasnotyetrearrangedBcellreceptorTransientlyexpressedwhenVHDHJHCHmisproductivelyrearrangedIga&IgbsignaltransductionmoleculesCHmHeavychainVHDHJHLightchainVLJLCLVpreBl5Pre-Bc

8、elldevelopmentiscoupledwithrearrangementofheavy-chainBcelldevelopmentiscoupledwithrearrangementofheavy-chainBcelldevelopmentiscoupledwithrearrangementofheavy-chainBcelldevelopmentiscouple