浙江大学医学免疫学经典课件06-细胞因子

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1、CytokinesandtheirreceptorsLieWang(汪洌）浙江省杭州市浙江大学紫金港校区医学院科研楼A810-814医学院免疫学研究所IntroductiontocytokinesCategoriesofCKsBiologicalfunctionofCKsCytokinereceptorClinicalapplicationofcytokinesIntroductiontocytokinesCytokine(CK)Cytokinesaresmallsolubleproteinsthatmedi

2、ateimmuneandinflammatoryreactionsandareresponsibleforcommunicationsbetweenleukocytesandothercells.Cytokinesworkbybindingtoatargetcell.Therefore,foracytokinetohaveaneffect,twothingshavetooccur:ThecytokineneedstobepresentthereThetargetcellneedstohaveareceptor

3、onitssurfaceTherefore,regulationcanoccurateitherstep.TheresearchofCKcanhelpustoclarifythemechanismofimmuneresponsesatthemolecularlevelandtounderstandthepathogenesisofsomediseases.ManyCKsandtheirantagonistscanbeusedinthetreatmentofmanydiseases(suchascancer,i

4、nfection,autoimmunediseases)andtopromotehemopoiesis,etc.Accordingtotheirsource1)Monokine2)LymphokineAccordingtotheirfunction1)Colonystimulatingfactor2)Interleukin3)Interferon4)Tumornecrosisfactor5)Growthfactor6)ChemokineGeneralpropertiesofCKsSmallproteins(M

5、W:approx.8-30KD)Extremelypotent,actingat10-9~10-15MTheproductionistransientandtightlyregulatedAutocrine,paracrineorendocrineCytokineactions:Pleiotropy,Redundancy,SynergyandAntagonismMannerofaction1)Autocrine:IL-2ThTh2)Paracrine:IL-12DCTh3)Endocrine:IL-1,TNF

6、-Undercertaincircumstances(e.g.septicshock),largeamountsofCKs(suchasTNF-)areproduced,theymaybeactivedistantfromtheirsiteofsecretion.Cytokineactions1)PleiotropyActsonmorethanonecelltype(IL-4)2)RedundancyMorethanonecytokinehavethesameaction(IL-2,IL-7,IL-15)

7、3)SynergyTwoormorecytokinescooperatetoproduceaneffectthatisdifferentorgreaterthanthecombinedeffectofthetwocytokineswhenfunctioningseparately(IL-3andCSF)4)AntagonismTwoormorecytokinesworkagainsteachother(IL-4andIFN-)Thecytokinenetwork:Manycytokineshavemulti

8、plefunctionsandapparentredundancyofactionsformingacomplexcommunicationnetwork.CategoriesofCKsCKsareclassifiedinto6functionalcategoriesInterleukin(IL)Interferon(IFN)Tumornecrosisfactor(TNF)Colonystimula