浙江大学医学免疫学经典课件免疫16-免疫调节

《浙江大学医学免疫学经典课件免疫16-免疫调节》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、免疫调节（Immunoregulation）王迪浙江大学免疫学研究所wangdi80@gmail.comhttp://mypage.zju.edu.cn/wangdi/Theabilityoftheimmunesystemtosenseandregulateitsownresponses:1.Todeterminethetypeandscaleofaresponse;2.ToensureFastResponseuponexogenousantigenstimulation;3.Toswitchofftheresponseproper

2、lyandrestoretheimmunesystemtoarestingstatewhentheresponsetoagivenantigenisnolongrequired.ImmunoregulationImmunoregulationImmuneResponseandRegulation:IncludingPositive&Negativeregulation.Positiveregulationensuresfastresponse.Whilenegativeregulationaftertheclearanceofinf

3、ectionisveryessentialforrestoretheimmunehomeostasis.Immunoregulationandintervention:Upontheunderstandingofimmunoregulationmechanisms,wecandeliberatelyenhanceortakeawayoneofthecontroltoenhanceorblockanimmuneresponse(TumororTransplantationrejection).ImmunoregulationandDi

4、sease:Sinceimmuneregulationisachievedatmanydifferentlevelsbydifferentmechanisms,anydefectinthissystemwillcauseanimmunedisorder.ImmuneregulationhappensatdifferentstagesofanimmuneresponseDuringInnateImmuneResponseTLRmediatedinflammatoryresponseCytokinesignalingDuringadap

5、tiveimmuneresponseByInhibitoryreceptorsByTregsOtherImmuneregulationmechanismsRegulationbyantibodybytheidiotypeandanti-idiotypenetworkImmuneResponseToll-likereceptorsandrecognitionofpathogensK.Takeda&S.Akira,Cell.Microbiol.5:143-53,2003diacyl-triacyl-lipopeptide酰基脂肽；fla

6、gellin:鞭毛蛋白;LPS:脂多糖(Lipopolysaccharides)Toll-likereceptorsignalingpathwaysMyD88pathwayandTRIFpathway;TranscriptionfactorsCytokineexpressionInnateresponseiscriticalforaneffectiveimmuneresponse.Excessiveresponseleadtoendotoxicshock(sepsis)：Sepsis（败血症）isaseriousmedicalcon

7、ditionthatischaracterizedbyawhole-bodyinflammatorystate(calledasystemicinflammatoryresponsesyndromeorSIRS)andthepresenceofaknownorsuspectedinfection.Thebodymaydevelopthisinflammatoryresponsetomicrobesintheblood,urine,lungs,skin,orothertissues.Alaytermforsepsisisbloodpo

8、isoning.TheKeyeventforinnateimmuneresponse:RecognitionofmicrobepatternsbypatternrecognitionreceptorsincludingTLR.Regu