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时间:2019-09-06
《肺炎支原体感染与儿童咳嗽变异性哮喘发病关系的研究》由会员上传分享,免费在线阅读,更多相关内容在工程资料-天天文库。
1、肺炎支原体感染与儿童咳嗽变异性哮喘发病关系的研究湖南省郴州市第一人民医院北院湖南郴州423000【摘要】目的探讨肺炎支原体(MP)感染与儿童咳嗽变异性哮喘(CVA)发病的关系。方法选取2013年1月-2015年12月在我院儿科门诊就诊或住院的咳嗽变异性哮喘患儿50例,对照组50例为观察组,为同期在我院儿科门诊就诊的上呼吸道感染患儿,采用明胶颗粒凝集试验检测两组患儿血清肺炎支原体IgM(MP-IgM)抗体,同时采用同位素放射免疫法和血球分析仪常规法测定CVA患儿血清总IgE水平和外周血嗜酸粒细胞计数。结果观察组MP—IgM阳性例数19例,阳性率为38.0%;对照组阳性例数10例,阳性率为20
2、.0%。经卡方检验两组比差异有统计学意义(P<0.01),CVA患儿MP感染率明显高对照组。观察组IMP—IgM阳性CVA患者的血清总IgE水平和周血嗜酸粒细胞计数均明显高于MP—IgM阴性CVA患两组比较,差异有统计学意义(P<0.01)o结论肺炎支原体感染与儿童咳嗽变异性哮喘有密切相关性。【关键词】咳嗽变异性哮喘;肺炎支原体;儿童感染[AbstractJObjectiveToinvestigatetherelationshipbetweenMycoplasmapneumoniae(MP)infectionandtheincideneeofcoughvariantasthma
3、(CVA)inchildren.Methods・2015January2013toDecember2004inourhospitalpediatricclinicorhospitalcoughvariantasthmain50cases,controlgroupof50casesastheobservationgroup,forthesameperiodinourhospitalpediatricclinicofupperrespiratorytractinfectioninchildren,thegelatinparticleagglutinationtestfordetectionof
4、twogroupsofchildrenwithpneumoniainserumIgMofMycoplasmaantibodies(MPIgM).Atthesametime,theconventionalradioimmunoassayandthebloodcellanalyzermethodeosinophilcellcountdeterminationcoughvariantasthma(CVA)serumlevelsoftotalIgEandperipheralbloodeosinophil.Resultsintheobservationgroup,IgM-MPpositivecase
5、swere19cases,positiveratewas38%;thecontrolgroupwas10cases,thepositiveratewas20%.Afterchisquaretest,thedifferencewasstatisticallysignificantbetweenthetwogroups(P<0.01),theMPinfectionratewassignificantlyhigherintheCVAgroup.ObservationgroupIgM-CVApositiveIMPpatientswithserumtotalIgElevelsandperiph
6、eralbloodeosinophilscountweresignificantlyhigherthantheIgM・CVAnegativeMPpatientswithtwogroupsofcomparison,thediffereneewasstatisticallysignificant(P<0.01).ConclusionMycoplasmapneumoniaeinfectioniscloselyrelatedtothecoughvariantasthmainchildren.[Keywords]:coughvariantasthma;Mycoplasmapneumoniae;
7、infectionofchildren肺炎支原体(MP)是引起幼儿和儿童呼吸道及全身性疾病的常见病原体之一,MP感染的发病率在儿童中呈逐年增高趋势[1]。咳嗽变异性哮咳嗽变异性哮喘(coughvariantasthma,CVA)是过敏性哮喘中的一种特殊类型,在临床上通常表现为持续性咳嗽或咳嗽反复发作等特征[2],且多在俊间或清晨阵发性发作,是小儿慢性咳嗽的常见病因之一,近年来发病呈逐年上升趋势。据相关文献报道,肺炎支原体
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