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1、ReviewArticleCancermetabolism:KeyplayersinmetabolicreprogrammingTomoyoshiSoga1InstituteforAdvancedBiosciences,KeioUniversity,Tsuruoka,Japan(ReceivedOctober11,2012RevisedDecember3,2012AcceptedDecember10,2012AcceptedmanuscriptonlineDecember20,2012Articlefirstp
2、ublishedonlineJanuary31,2013)(7)Over80yearsago,Warburgdiscoveredthatcancercellsgeneratecells.ThisreviewcoverstheaccumulatedfindingsregardingATPthroughtheglycolyticpathway,eveninthepresenceofoxy-keytranscriptionfactorsandmetabolicenzymesthatinducegen.Thefindin
3、gofthisphenomenon,termedthe“Warburgalterationsincancermetabolism,whichcanbeattractivetar-effect,”stimulatedmuchresearchontumorigenesis,butfewgetsforcancertherapy.explanationswereforthcomingtoexplaintheobservation.Recently,advanceddevelopmentsinmolecularbiol
4、ogyandhigh-TheWarburgEffectthroughputmolecularanalyseshaverevealedthatmanyofthesignalingpathwaysalteredbygenemutationsregulatecellOneoftheprominentcharacteristicsofrapidlygrowingtumormetabolismincancer.Furthermore,mutationsinisocitratedehy-cellsistheircapac
5、itytosustainhighratesofglycolysisfordrogenase1and2wereshowntoelevate2-hydroxyglutarate,ATPgeneration,irrespectiveofoxygenavailability.Thisphe-(2,8,9)whichledtochangesina-ketoglutarate-dependentdioxygenasenomenonisknownastheWarburgeffect.Thischaracter-enzyme
6、activity,resultinginanincreasedriskofmalignantisticseemstobeageneralpropertyofhighlymalignant(10)tumors.Althoughthesefindingsledtoarenewedinterestincan-tumors,independentoftheircarcinogenicorigin.Infact,cermetabolism,ourknowledgeonthespecificsoftumormetab-sig
7、nificantactivationofglycolysiswasobservedinhumanolismisstillfragmented.Thispaperreviewsrecentfindingscancertissuesthroughtheuseofaleading-edgemetabolomicrelatedtokeytranscriptionfactorsandenzymesthatplayanprofilingmethodbasedoncapillaryelectrophoresismassspec-
8、(11–13)importantroleintheregulationofcancermetabolism.(Cancertrometry.Sci2013;104:275–281)Inthepresenceofoxygen,mostcellsprimarilymetabolizeglucosetopyruvateinglycolysisandthencompletelyoxidizemostofth
