epigenomic reprogramming during pancreatic cancer progression

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1、EpigenomicreprogrammingduringpancreaticcancerprogressionlinksanabolicglucosemetabolismtodistantmetastasisYinDan2017.10.14pancreatic ductal adenocarcinoma(PDAC)IntroductionStageT4StageT1StageT2StageT3StageT5EpigenomicregulationDNA-hypomethylatedblocksLargeheteroc

2、hromatindomainsincludingLOCKs1RESULTGlobalepigeneticreprogrammingduringtheevolutionofdistantmetastasis2RESULTTheepigenomiclandscapeofPDACsubclonalevolutionLOCKs：(LargeOrganizedChromatinK9-modifications)occupiedapproximatelyhalfofthegenomeH3K9me2ECDs：(gene-richeu

3、chromatindomains)occupiedone-thirdofthegenomeH3K27ac&H3K36me3LargeLOCKdomain：situatedwithinDNAhypomethylatedblockssimilartootherLOCKs,theydifferedinseveralotherrespects3RESULTReprogrammedchromatindomainsspecifymalignantheterogeneity4RESULTAnabolicglucosemetaboli

4、smcontrolsepigeneticstateandtumorigenicity6ANReversalReversalPGD(oxPPP)DiscussionLOCKs:histoneH3K9、DNAmethylationGeneregulatorymodifications:regionalchangestumorigenicityTHANKS