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《HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer.PDF》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、MOLECULARONCOLOGY9(2015)586e600availableatwww.sciencedirect.comScienceDirectwww.elsevier.com/locate/moloncHERfamilykinasedomainmutationspromotetumorprogressionandcanpredictresponsetotreatmentinhumanbreastcancerab,c,haDelphineR.Boulbes,StefanT.Arold,GauravB.Chauhan,KorinaaaeaV.Blachno,Nanf
2、uDeng,Wei-ChaoChang,QuanriJin,dddTzu-HsuanHuang,Jung-MaoHsu,SamuelW.Brady,ab,c,ifdChandraBartholomeusz,JohnE.Ladbury,SteveStone,DihuaYu,dg,Mien-ChieHung,FranciscoJ.Esteva*aDepartmentsofBreastMedicalOncology,TheUniversityofTexasMDAndersonCancerCenter,Houston,TX77030,USAbDepartmentsofBioche
3、mistry&MolecularBiology,TheUniversityofTexasMDAndersonCancerCenter,Houston,TX77030,USAcDepartmentsofCenterforBiomolecularStructureandFunction,TheUniversityofTexasMDAndersonCancerCenter,Houston,TX77030,USAdDepartmentsofMolecular&CellularOncology,TheUniversityofTexasMDAndersonCancerCenter,H
4、ouston,TX77030,USAeGraduateInstituteofCancerBiologyandCenterforMolecularMedicine,ChinaMedicalUniversityHospital,Taichung,404TaiwanfMyriadGenetics,SaltLakeCity,UT84108,USAgLauraandIsaacPerlmutterCancerCenter,NewYorkUniversityLangoneMedicalCenter,160E.34thStreet,NewYork,NY10016,USAhDivision
5、ofBiologicalandEnvironmentalSciencesandEngineering,ComputationalBioscienceResearchCenter(CBRC),KingAbdullahUniversityofScienceandTechnology(KAUST),Thuwal,SaudiArabiaiSchoolofMolecularandCellBiology,UniversityofLeeds,LeedsLS29jT,UKARTICLEINFOABSTRACTArticlehistory:ResistancetoHER2-targeted
6、therapiesremainsamajorobstacleinthetreatmentofHER2-Received25September2014overexpressingbreastcancer.UnderstandingthemolecularpathwaysthatcontributetoReceivedinrevisedformthedevelopmentofdrugresistanceisneededtoimprovetheclinicalutilityofnovelagents,24October2014andtopredictthesuccessofta
7、rgetedpersonalizedtherapybasedontumor-speciÞcmuta-Accepted24October2014tions.LittleisknownabouttheclinicalsigniÞcanceofHERfamilymutationsinbreastcan-Availableonline11November2014cer.BecausemutationswithinHER1/EGFRarepredictiveofresponsetotyrosinekinaseinhibitors(TKI
