ABSTRACT-HarlemChildrenSociety摘要-哈莱姆儿童协会

《ABSTRACT-HarlemChildrenSociety摘要-哈莱姆儿童协会》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、CreatinganIon&MolecularSensorByCombiningPhenylMercaptoacetamide&BenzylMercaptoacetamideLigandswithPreferableMetalsSubmittedby:ChrisRocaMentor:DuncanQuarless,Ph.D.UndergraduateAsst.Mentor:AliciaBowenABSTRACTPhenylmercaptoacetamide(PMA)&Benzylmercaptoacetamide(BMA)weresynthesizedtoobservetheirim

2、itativerelevanceforfabricatingthestructureandreactivityofmetallocysteinateproteinsthatareinvolvedinmetaltransport.Theseligandswereusedtoobserveifthetypeofreactionthattakesplacebetweenthemandthemetalcations,whichareZinc(Zn2+)andCobalt(Co2+),canproduceaniondetectingmolecule.XylenolOrangewasuseda

3、sacolorindicatortodeterminetheextinction(metalconcentrationdependence)whichisusedfromBeer’slawA=EBCandexaminethevisiblespectroscopyofthevarioussolutions,whichdeterminestherelativeconcentrationofcomplexedandfreeindicators.Althoughnomajorresultsareyetfound,zincappearstobetheleastdiscriminateofth

4、emetalcationswithrespecttoxylenolorange.CobaltshowedalowerextinctionthanZincwhichmeantmoreconcentrationwasneededthanZinc.Thepurposeofsuchanexperimentistoseeiftheseligandscanbeanalternativeforiondetectionwhencombinedwithametal,whichforthemomentseemstobeZinc.INTRODUCTIONIonrecognitioncontinuesto

5、beamajorresearchgoalformanysupramolecularchemistgroupsaroundtheworld.Phenylmercaptoacetamide(PMA)&Benzylmercaptoactamide(BMA)areligandsorinotherwordstheyareamoleculethatbondstothecentralmetalatomofacompound.Whatisexpectedtohappenisthattheligands,BMAandPMA,wouldreactwiththemetals,Zinc(Zn)andCob

6、alt(Co),toformamoleculethatdetectsspecificionswhenthetwocomeintocontact.Ifsuccessfulthisexperimentcanhelpproduceaniondetectingagentthatisanovelsulfurbasedligand,andtheseassayswilllikelyhaverelevanceinanalytical,environmentalchemistry,aswellasbiomedicalimaginganddrugdiscovery.MATERIALSCHEMICALS

7、AnilineBenzylamineThioglycolicacid(mercaptoaceticacid)CobaltacetateZincacetatepH5bufferMethanolLABEQUIPMENTThermometersWeighingscalesAssortedglassware(Volumetricflasks,Erlenmeyerflasks,Buchnerfunnels,etc)UltravioletLight(UV/vis)spectrop