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1、·1252·MODERNONCOLOGY,Oct.2006,VoI114,NO110HCVC蛋白、p53、Mdm2、p14和p21在原发性肝癌中的表达及相关性111121张志培,程庆书,黄立军,徐鉷,王文勇,王小平ARFWAF1/CIP1ExpressionofHCVcore,p53,Mdm2,p14andp21proteinsinHCCandtheircorrelation11112ZHANGZhi-pei,CHENGQing-shu,HUANGLi-jun,XUHong,WANGWen-yong,WANGXiao-1ping12DepartmentofThor
2、acicSurgery,TangduHospital,FourthMilitaryMedicalUniversity,Xi'an710038,China;DepartmentofPatholo2gy,SchoolofBasicMedicine,FourthMedicalUniversity,Xi'an710032,ChinaARFWAF1/CIP1【Abstract】Objective:ToinvestigateexpressionofHCVcore,mutantp53,Mdm2,p14p21proteinsandcorrelationoftheseprotein
3、sintheHCCtissues;toexploreweatherHCVcoreproteinaffectsexpressionofmutantARFWAF1/CIP1p53,Mdm2,p14p21proteinsandtheirclinicsignificance.Methods:Tocollectparaffin-embeddedtis2ARFWAF1/CIP1suesof42caseswithHCCanddeterminetheexpressionofHCVcore,mutantp53,Mdm2,p14andp21proteinswithimmunohist
4、ochemicalmethod,usingEnVisionmethod;analyzethecorrelationoftheseproteinsbysta2ARFWAF1/CIP1tisticmethods.Results:ThepositiveexpressionofHCVcore,mutantp53,Mdm2,p14p21proteinsprima2ARFrilyliesinthenucleus;thepositiveratesofmutantp53,Mdm2,p14,proteinexpressionwererespectively40.5%,47.62%,
5、75.57%,45.24%,19.05%intheHCC,andsotherewassignificantlydifference(P<0.000)amongthefivegroupsofproteinexpression;pvaluesofcorrelationshiptestofpositiveintensitybetweenHCVcoreandmu2ARFWAF1/CIP1tantp53,HCVcoreandp14HCVcoreandp21expressionwererespectively0.000,0.000,0.43,whilethecorrelati
6、oncoefficientswererespectively0.67,0.64,-0.29;pvaluesofcorrelationshiptestofpositiveintensitybe2tweenmutantp53andMdm2,p53andp21proteinexpressionwererespectively0.000,0.174,whilethecorrelationcoefficientswererespectively0.72,-0.45.Conclusion:HCVcoreproteinprobablypromoteswildtype'stran
7、sfertomutanttypeofp53andits'expression;HCVcoreproteintogetherwithmutationp53alsoprobablypromotesexpres2ARFsionofMdm2protein,whilethecoreproteinmaybeaffecttheexpressionofp14protein;thehighabsenceofWAF1p21proteinwasverycommoninHCC,andtheHCCrelatedwithHCViscorrelatedwithp53pathwaychange,
8、withC
