ACE研究将指导心血管疾病全面防治的新策略

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1、ProfessorRuryHolmanUniversityofOxford,UKProfessorChangYuPanProfessorDaYiHuChinesePLAGeneralHospitalUniversityofPekingChinaChinaRationaleforACETrialAccumulatingevidencesuggeststhereisacloseassociationbetween“prediabetes”andcardiovasculardisease(CVD)Treatingconventionalriskfactorsintype2diab

2、etesdoesnotreduceCVDrisktothesamelevelasinanon-diabeticpopulationPostprandialhyperglycaemiamayexplaintheexcessriskseenindiabetesand“prediabetes”Acarbosehasbeenreported*toreduceCVDriskinindividualswith“prediabetes”,butitsimpactonnewCVDeventsinindividualswith“prediabetes”andexistingCVDandisu

3、nknown*ChiassonJLetal.JAMA2003;290(4):486-94ACETrialManagementCoordinatingCentreDiabetesTrialsUnit,UniversityofOxfordACEChineseProjectOfficeOxfordUniversity(Beijing)Science&TechnologyLimitedFunding&StudyMedicationBayerHealthCareChina&BayerScheringPharmaStudyDesignDouble-blind,multi-centre,

4、randomised,controlled,clinicaloutcometrialcomparingacarboseversusplaceboInvestigatordesignedandledacademictrialIndependentdatacollection,analysisandreportingConductedinMainlandChinaandHongKong7,500patientsin~150cardiovascularcentresMinimumpatientfollowupfouryearsEventdriven(904adjudicatedp

5、rimaryevents)RuryHolmanUKDiabetologist(Chair)DaYiHuChinaCardiologist(Co-Chair)ChangYuPanChinaDiabetologist(Co-Chair)JiaLunChenChinaDiabetologist(Honouredadviser)JulianaChanHongKongDiabetologistJean-LouisChiassonCanadaDiabetologistJunBoGeChinaCardiologistHertzelGersteinCanadaDiabetologistJo

6、hnMcMurrayUKCardiologistLarsRydénSwedenCardiologistMichalTenderaPolandCardiologistJaakkoTuomilehtoFinlandEpidemiologistWenYingYangChinaDiabetologistJoanneKeenanUKDTUProjectManagerDieterNeuserGermanyBayerProjectManagerThorstenPetruschkeGermanyBayerProjectManagerACESteeringCommitteeMajorIncl

7、usionCriteriaConfirmedcardiovasculardisease(CVD)HistoryofmyocardialinfarctionPreviousunstableanginaCurrentstableanginaImpairedglucosetolerance(IGT)onanoralglucosetolerancetestwith:Fastingplasmaglucose<7.0mmol/l2-hourplasmaglucose≥7.8and≤11.1mmol/lMaleorfemale,