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1、急性循环衰竭与休克上海交通大学医学院附属瑞金医院中法生命科学和基因组研究中心陆一鸣教授、主任医师、博士生导师概述•背景:–1982年休克诊断标准已不适用,需新的诊断标准–2014年血流动力学监测共识提出诊断新观点•中国急诊休克(急性循环衰竭)临床操作指南(2015)–强调诊疗需以病理生理为基础–强调乳酸在休克(ACF)诊疗中的价值–强调个体化诊断与治疗急性循环衰竭(ACF)即休克•各种原因导致的急性循环系统功能障碍,氧输送不能保证机体代谢需要,引起细胞水平缺氧1,2•休克最佳的定义就是急性循环衰竭1,2•休克是ACF的临床
2、表现3,41.PernerA,etal.ActaAnaesthesiolScand.2015;59(3):274-85.2.VincentJL,etal.CritCareMed.2012;16(6):239.3.VincentJL,etal.NEnglJMed2013;369:1726-34.4.CecconiM,etal.IntensiveCareMed.2014;40(12):1795-815.CURRENTSTATUSOFACUTECIRCULATORYFAILUREPRESENTEDATERINCHINAPROFY
3、I-MINGLURUIJINHOSPITALSHANGHAIJIAOTONGUNIVERSITYSCHOOLOFMEDICINE流行病学•流调时间:2013/12/22-2014/4/20中心数:33N=1261•急诊休克(ACF)发生率0.35%(中国首个数据)•按休克类型的发生率(2013/12/6-12一周内,180休克/51906急诊病人)分类患者数发生率(%)占比(%)低血容量性出血性610.11930.7创伤性470.04411.4分布性脓毒性670.13735.1过敏性70.0133.5烧伤性10.0020.
4、5神经源性90.0174.5心源性290.05614.4•病死率19.4%ClassificationofshockatER(1261pts.)ProportionProportionTypeNo.TypeNo.(%)(%)Singletype108887.39Combined2types15412.37Hemorrhagic+traumaticHemorrhagic33126.59987.87Septic44035.34Cardiogenic+septic252.01Cardiogenic22818.31Hemorrha
5、gic+septic161.29Traumatic332.65others151.19Neurogenic262.09Combined3types30.24Allergic181.45Burn120.96Diagnosiscriteriaofshock•905pts(71.8%)met”China1982criteria”ProportionDataProportion1.1982criteria:a+2/3(b,c,d)+2/3(e,f,g)criteriametunmettomeetoffofdateoffa.Basi
6、cdiseasetoinduceshockcriteriab.Abnormalconsciousness1a12371598.190.7c.Tachycardia,>100bpmorcann’t1b78542762.3493.9touchd.Coldlimbs,capillaryrefilltime>2s,1c99021278.5594.7bluishskin,palemucosa,amountofurine<30ml/h1d93027473.8574.5e.SBP<80mmHg1e85036867.4433.4f.Pul
7、sepressure<20mmHgg.SBPdecrease>30%inhypertension1f31381524.813310.5pts.1g37569929.718714.82.Shockoccurswithin72hafterarrivingatER211646292.3352.8VitalsignsofshockpatientseffectiveeffectivePtsProportionPtsProportioncharacteristicsproportioncharacteristicsproportion
8、number(%)number(%)(%)(%)T(℃)SBP(mmHg)<=3634327.227.4<7027121.521.936.1-3751140.540.770-7945736.236.937.1-3821417.017.180-8926220.821.2>=38.118614.814.89