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《Preparation characterization and pharmacokinetic studies of linalool loaded nanostructured lipid carriers制备、表征及 芳樟醇负荷的药代动力学研究 纳米结构脂质载体》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、PharmaceuticalBiologyISSN:1388-0209(Print)1744-5116(Online)Journalhomepage:http://www.tandfonline.com/loi/iphb20Preparation,characterizationandpharmacokineticstudiesoflinalool-loadednanostructuredlipidcarriersFengShi,YingyingZhao,CalebKesseFirempong&XimingXuTocitethisarticle:
2、FengShi,YingyingZhao,CalebKesseFirempong&XimingXu(2016)Preparation,characterizationandpharmacokineticstudiesoflinalool-loadednanostructuredlipidcarriers,PharmaceuticalBiology,54:10,2320-2328,DOI:10.3109/13880209.2016.1155630Tolinktothisarticle:https://doi.org/10.3109/13880209
3、.2016.1155630Publishedonline:17Mar2016.SubmityourarticletothisjournalArticleviews:504ViewCrossmarkdataCitingarticles:4ViewcitingarticlesFullTerms&Conditionsofaccessandusecanbefoundathttp://www.tandfonline.com/action/journalInformation?journalCode=iphb20PHARMACEUTICALBIOLOGY,2
4、016VOL.54,NO.10,2320–2328http://dx.doi.org/10.3109/13880209.2016.1155630RESEARCHARTICLEPreparation,characterizationandpharmacokineticstudiesoflinalool-loadednanostructuredlipidcarriersFengShi*,YingyingZhao*,CalebKesseFirempongandXimingXuDepartmentofPharmaceutics,SchoolofPharm
5、acyCenterforNanoDrug/GeneDeliveryandTissueEngineering,JiangsuUniversity,Zhenjiang,PRChinaABSTRACTARTICLEHISTORYContextLinalool(LL)isassociatedwithnumerouspharmacologicalactivities.However,itspoorsolubilityReceived15August2015usuallyresultsinpoorbioavailability,andfurtherlimit
6、editsapplications.Accepted13February2016ObjectiveToreducevolatilizationandimprovebioavailabilityofLL,linalool-loadednanostructuredlipidPublishedonline15Marchcarriers(LL-NLCs)wereprepared.2016MaterialsandmethodsLL-NLCswerepreparedusinghigh-pressurehomogenizationmethodandopti-K
7、EYWORDSmizedviaresponsesurfacemethodology-centralcompositedesign,followedbycharacterization,includingEssentialoil;high-pressureparticlesize(PS),zetapotential(ZP),transmissionelectronmicroscope(TEM),X-raydiffraction(XRD),differ-homogenization;response1entialscanningcalorimetr
8、y(DSC)andinvitroreleasestudy.Ratswereadministered300mgkgLLsurfaceme
