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《Microsatellite Instability as a Biomarker for PD-1Blockade微卫星不稳定性作为PD-1的生物标志物 封锁》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、ReviewClinicalCancerResearchMicrosatelliteInstabilityasaBiomarkerforPD-1Blockade1232,3JonathanC.Dudley,Ming-TsehLin,DungT.Le,andJamesR.EshlemanAbstractInitialresultsbyLeandcolleagues,whichwerepublishedinwithLynchsyndromeorsomatichypermethylationoftheMLH1theJune25,2015issueoftheNe
2、wEnglandJournalofMedicine,promoter.Theresultisacancerwitha10-to100-foldincreaseinreportsignificantresponsesofcancerswithmicrosatelliteinsta-mutations,associatedinthecolonwithpoordifferentiation,anbility(MSI)toanti–PD-1inhibitorsinpatientswhofailedintenselymphocyticinfiltrate,andasu
3、periorprognosis.Diag-conventionaltherapy.Thisfindingfitsintoabroaderbodyofnosticapproacheshaveevolvedsincetheearly1990s,fromresearchassociatingsomatichypermutationandneoepitoperelyingexclusivelyonclinicalcriteriatoincorporatingpathologicformationwithresponsetoimmunotherapy,withthea
4、ddedfeatures,PCR-basedMSItesting,andimmunohistochemistrybenefitofrelyingonasimple,widelyuseddiagnostictest.ThisforlossofMMRcomponentexpression.TumortypescanbereviewsurveysthepathogenesisandprognosticvalueofMSI,groupedintocategoriesbasedonthefrequencyofMSI,fromdiagnosticguidelinesf
5、ordetectingit,andthefrequencyofMSIcolorectal(20%)andendometrial(22%–33%)tocervical(8%)acrosstumors,withthegoalofprovidingareferenceforitsuseasandesophageal(7%)toskinandbreastcancers(0%–2%).abiomarkerforPD-1blockade.MSIusuallyarisesfromeitherIfinitialresultsarevalidated,MSItesting
6、couldhaveanexpandedgermlinemutationsincomponentsofthemismatchrepairroleasatoolinthearmamentariumofprecisionmedicine.(MMR)machinery(MSH2,MSH6,MLH1,PMS2)inpatientsClinCancerRes;22(4);813–20.Ó2016AACR.DisclosureofPotentialConflictsofInterestNopotentialconflictsofinterestweredisclosed.
7、Editor'sDisclosuresThefollowingeditor(s)reportedrelevantfinancialrelationships:J.R.Grandis—None.CMEStaffPlanners'DisclosuresThemembersoftheplanningcommitteehavenorealorapparentconflictsofinteresttodisclose.LearningObjectivesUponcompletionofthisactivity,theparticipantshouldhaveabett
8、erunderstandingofthepathogenesisandclini
