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《Enhanced Sensitivity of the MRLMpJ Mouse to theNeuroplastic and Behavioral Effects of Chronic增强MRL_MPJ小鼠的灵敏度 慢性神经行为和行为的影响 抗抑郁治疗》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、Neuropsychopharmacology(2009)34,1764–1773&2009NaturePublishingGroupAllrightsreserved0893-133X/09$32.00www.neuropsychopharmacology.orgEnhancedSensitivityoftheMRL/MpJMousetotheNeuroplasticandBehavioralEffectsofChronicAntidepressantTreatmentsDarrickTBalu1,GeorgiaEHodes2,BrianTAnderson2andIrwi
2、nLucki*,1,212DepartmentofPharmacology,UniversityofPennsylvania,Philadelphia,PA,USA;DepartmentofPsychiatry,UniversityofPennsylvania,Philadelphia,PA,USAChronicadministrationofantidepressantdrugsproducechangesinneuroplasticityandbehaviorinrodents,effectsthatmaybeassociatedwiththeslowemergence
3、ofclinicaltherapeuticeffects.Owingtotheuncertaintyovertheeffectsofchronicantidepressanttreatmentsinmice,theseexperimentscomparedtheregulationofneurogenesis,neurotrophinlevels,andbehaviorproducedbychronicantidepressanttreatmentsbetweentwoinbredmousestrains,MRL/MpJandC57BL/6J.TheMRL/MpJstrai
4、nisassociatedwithenhancedwoundhealingandtissueregeneration,whereasC57BL/6Jmiceareusedcommonlyforbehavioralstudies.Proliferationandsurvivalofhippocampalprogenitorcellsweremeasuredusingflowcytometry,anewplatformthatrapidlyquantifiestheincorporationof5-bromo-2-deoxyuridine(BrdU).Hippocampalce
5、llproliferationwasincreasedsignificantlyafterchronicadministrationoffluoxetine(FLX:5,10mg/kg,intraperitoneal(i.p.),b.i.d.)ordesipramine(DMI:5,10mg/kg,i.p.,b.i.d.)for21daysinMRL/MpJmice,butnotinC57BL/6Jmice.Hippocampalprogenitorcellsbornpriortochronicantidepressanttreatmentswerenotaffectedi
6、neithermousestrain.Proteinlevelsofbrain-derivedneurotrophicfactor(BDNF)inMRL/MpJmicewereelevatedsignificantlyinthefrontalcortex,hippocampus,andamygdalaafterchronicFLXtreatment,butincreasedonlyinthefrontalcortexbychronicDMI.Incontrast,BDNFlevelsinC57BL/6Jmiceweredecreasedinthehippocampusand
7、increasedintheamygdalaafterchronicFLX,andweredecreasedinthebrainstemafterchronicDMI.Novelty-inducedhypophagia(NIH)wasusedtoexamineabehavioraleffectproducedbychronicantidepressanttreatment.MRL/MpJmice,chronicallyadministeredFLXorDMI,hadsignificantlyshorterlaten
