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1、ARTICLEReceived8Feb2016
2、Accepted12Jan2017
3、Published6Mar2017DOI:10.1038/ncomms14581OPENGenomiccharacterisationofEm-MycmouselymphomasidentifiesBcorasaMycco-operativetumour-suppressorgeneMarcusLefebure1,2,*,RichardW.Tothill1,2,3,*,ElizabethKruse1,EdwinD.Hawkins4,JakeShortt1,5,Geo
4、ffreyM.Matthews6,GarethP.Gregory1,BenjaminP.Martin1,MadisonJ.Kelly1,IzabelaTodorovski1,MariaA.Doyle1,RichardLupat1,JasonLi1,JanSchroeder4,MeaghanWall7,8,StuartCraig1,GretchenPoortinga1,DonCameron1,MeganBywater1,LevKats1,2,MicahD.Gearhart9,VivianJ.Bardwell9,RossA.Dickins10,Ros
5、sD.Hannan1,11,AnthonyT.Papenfuss1,2,4&RickyW.Johnstone1,2TheEm-MycmouseisanextensivelyusedmodelofMYCdrivenmalignancy;howevertodatetherehasonlybeenpartialcharacterizationofMYCco-operativemutationsleadingtospontaneouslymphomagenesis.HerewesequencespontaneouslyarisingEm-Myclymph
6、omastodefinetransgenearchitecture,somaticmutations,andstructuralalterations.WeidentifyfrequentdisruptivemutationsinthePRC1-likecomponentandBCL6-corepressorgeneBcor.Moreover,wefindunexpectedconcomitantmultigeniclesionsinvolvingCdkn2alossandothercancergenesincludingNras,KrasandBc
7、or.Thesefindingschallengetheassumedtwo-hitmodelofEm-MyclymphomaanddemonstrateafunctionalinvivoroleforBcorinsuppressingtumorigenesis.1ThePeterMacCallumCancerCentre,Melbourne,Victoria3000,Australia.2TheSirPeterMacCallumDepartmentofOncology,UniversityofMelbourne,Parkville,Victori
8、a3052,Australia.3DepartmentofPathology,UniversityofMelbourne,Parkville,Victoria3052,Australia.4TheWalterElizaHallInstituteofMedicalResearch,Parkville,Victoria3052,Australia.5SchoolofClinicalSciencesatMonashHealth,FacultyofMedicine,Nursing&HealthSciences,Clayton,Victoria3168,A
9、ustralia.6DanaFarberCancerInstitute,Boston,Massachusetts02115,USA.7VictorianCancerCytogeneticsService,StVincent’sHospital,Fitzroy,Victoria3065,Australia.8DepartmentofMedicine,StVincent’sHospital,UniversityofMelbourne,Parkville,Victoria3052,Australia.9DevelopmentalBiologyCente
10、r,MasonicCancerCenter,andDepartmentofGenetics,CellBiology,andDevelop
