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1、MixinginaMulti-InletVortexMixer(MIVM)forFlashNanoPrecipitation12212YingLiu,ChungyinCheng,YingLiu,RobertK.Prud’homme*andRodneyO.Fox*1DepartmentofChemicalEngineering,PrincetonUniversity2DepartmentofChemicalandBiologicalEngineering,IowaStateUniversityAbstractRapidprecipitationofbothorgani
2、candinorganiccompoundsathighsupersaturationrequireshomogenousmixingtocontroltheparticlesizedistribution.WepresentthedesignandcharacterizationofanewMulti-InletVortexMixer(MIVM).Thefour-streamMIVMallowscontrolofboththesupersaturationandthefinalsolventqualitybyvaryingstreamvelocities.Thed
3、esignalsoenablestheseparationofreactivecomponentspriortomixing.Finally,thedesignenablesmixingofstreamsofunequalvolumetricflows,whichisnotpossiblewithalternateconfinedimpingingjet(CIJ)mixinggeometries.WecharacterizethemixingperformanceoftheMIVMusingcompetitivefastreactions(thesocalled“B
4、ournereactions”).AdequatemicromixingisobtainedwithasuitablydefinedReynoldsnumberwhenRe>1600.TheexperimentalresultsarecomparedtoCFDsimulationsofthefluidmechanicsandparallelreactionsintheMIVM.Excellentcorrespondenceisfoundbetweenthesimulationandtheexperimentalresultswithnoadjustableparam
5、eters.TheCFDsimulationsprovideapowerfultoolfortheoptimizationofthesecomplexmixinggeometries.*Thecorrespondingauthors:RobertK.Prud’homme:Emailprudhomm@Princeton.EDUPhone(609)258-4577Fax(609)258-0211RodneyO.Fox:Emailrofoxiastate.eduPhone(515)294-9104Fax(515)294-2689Keywords:mixing,Multi-
6、InletVortexMixer(MIVM),Nanoprecipitation,ComputationalFluidDynamics(CFD),Reynoldsnumber,competitivereactions.IntroductionTheproductionofuniform-sizednanoparticlesofhydrophobicorganiccompoundsbyaneconomical,scalableprocessisaconsiderablechallenge.Itismotivatedbytheuseand1-4potentialuseo
7、fnanoparticlesindrugdelivery,especiallypoorlywatersolubledrugs,5-73,89,1011cosmetics,dyes,medicalimaginganddiagnostic,andpesticides.Oneofthe12advancedprocessestoproducenanoparticlesis“FlashNanoPrecipitation”,whichrequiresfastmixingoftwoormorestreamstocreatesupersaturation.Adissolveds
