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1、EsophagealCarcinomaMetastatictotheStomachAClinicopathologicStudyof35CasesTAKA0SAITO,MD,'TOSHlFUMlIIZUKA,MD,HOlCHlKATO,MD,ANDHlROSHlWATANABE,MDEsophagealcarcinomametastatictothestomachwasanalyzedin35patients.Tenwerediscoveredinsurgicalspecimensand25atautopsy.Allpatie
2、ntsweremenwithameanageof62years.Primarylesionsweremostfrequentlylocatedinthemiddleofthoracicesophagusandwerelargerthan7em.Undifferentiatedcarcinomawasfoundin29%ofthepatients.Localspreadoftheprimarylesionstoneighboringstructureswasseenin34%.Lymphaticinvasion,andintra
3、muralmetastaseswithintheesophagus,aswellaslymphnodemetastases,werepredominant.Metastaticlesionswithinthestomachweremostlylocatedinthegastriccardia,werelessthan2cmormorethan4cminsize,andresembledsubmucosaltumors.Gastricmetastasesoccasionallyspreadfromthesubmucosatone
4、ighboringstructures.Inspiteofaggressivetreatment,theprognosiswasextremelypoorbecauseofmultiplespreadofcarcinomatolocalregions,lymphnodes,anddistantorgans.Theclinicopathologiccharacteristicsofthisdiseaseandpossibletreatmentarediscussed.Cancer56:2235-2241,1985.CARCINO
5、MAOFTHEESOPHAGUSstillhasapoorprog-MaterialsandMethodsnosisdespiteattemptsataggressivetreatmentbyPatientssurgeryand/orradiationtherapy.'-5Oneofthemostcrit-icalreasonsforpoorprognosisisthatmetastaticspreadDuringtheperiodJuly1962toDecember1980,584ofesophagealcarcinomai
6、squitecommon."'*Alongwithpatientswithcarcinomaoftheesophagusunderwenteso-lymphnodemetastases,I3metastasesindistantorgansarephagectomyintheNationalCancerCenterHospitalalsofoundfrequently."Themostfrequentsiteofvisceral(NCCH).AsshowninTable1,stomachmetastasesofmetastas
7、esistheliver,followedbythelungandtheadrenalesophagealcarcinomawerediscoveredinsurgicalspeci-system.14Thepresenceofmetastaseswithinthestomachmensoftenpatients(group1).Theincidencewas1.7%fromesophagealcarcinomaisrare.Theincidencerangesofthe584patients.Later,sixofthete
8、npatientshadau-from0%to15%inautopsy~ases.~*~*'~'~*'~'~Thediscov-topsiesintheNCCHandautopsyrevealedthatinoneoferyofstomachmetastasisbeforea