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1、PediatricDiabetes2007:8:252–260#2007TheAuthorsAllrightsreservedJournalcompilation#2007BlackwellMunksgaardPediatricDiabetesOriginalArticleProteinmicroarrayanalysisasatoolformonitoringcellularautoreactivityintype1diabetespatientsandtheirrelativesVrabelovaZ,KolouskovaS,Bo¨hmovaK,Faresjo¨MK,SumnikZ,Zuz
2、anaVrabelovaa,PechovaM,KverkaM,ChudobaD,ZacharovovaK,StadlerovaG,StanislavaKolouskovaa,PithovaP,HladikovaM,StechovaK.ProteinmicroarrayanalysisasaKristynaBo¨hmova,atoolformonitoringcellularautoreactivityintype1diabetespatientsbMariaKarlssonFaresjo¨,andtheirrelatives.aPediatricDiabetes2007:8:252–260.
3、ZdenekSumnik,cMartaPechova,dBackground:AutoreactiveTcellshaveacrucialroleintype1diabetesMiloslavKverka,(T1D)pathogenesis.DanielChudobae,Objectives:TheaimofourstudywastomonitortheinvitroproductionKlaraZacharovovaf,ofcytokinesbyperipheralbloodmononuclearcells(PBMCs)afteraGabrielaStadlerova,stimulatio
4、nwithdiabetogenicautoantigens.gPavlinaPithova,Subjects:TenT1Dpatients(testedatthetimeofdiagnosisand6andh12monthslater),10first-degreerelativesoftheT1Dpatients,and10MarieHladikovaandacontrolsunderwentthestudy.KaterinaStechovaMethods:PBMCswerestimulatedwithglutamicaciddecarboxylase65aDepartmentofPaed
5、iatrics,2ndMedical(GAD65)aminoacids(a.a.)247–279,509–528,and524–543;proinsulinFacultyofCharlesUniversity,Prague,Theba.a.9–23;andtyrosinephosphatase(isletantigen-2)/R2a.a.853–872.CzechRepublic;DivisionofPaediatricsInterleukin(IL)-2,IL-4,IL-5,IL-6,IL-10,IL-13,interferon(IFN)-g,andDiabetesResearchCent
6、re,Facultytumornecrosisfactorb,transforminggrowthfactorb1,andgranulocyteofHealthSciences,Linko¨pingUniversity,ccolony-stimulatingfactor(GCSF)wereanalyzedbyproteinmicroarray.Linkoping,Sweden;}DepartmentofChemistryandBiochemistry,2ndResults:Differencesincytokine(s)poststimulatoryandmainlyinbasalMedic
7、alFacultyofCharlesUniversity,productionwereobservedinallgroups.ThemostprominentfindingsdPrague,TheCzechRepublic;Instituteofwereincontrols,thehigherbasallevelsofIL-2,IL-4,IL-5,IL-13,andMicrobiology,TheCzechA
