Glycaemic control in type 2 diabetes

《Glycaemic control in type 2 diabetes》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、main/0609_new17/11/06DiabetesGlycaemiccontrolintype2diabetesSearchdateJune2005AmaryllisCampbellQUESTIONSWhataretheeffectsofinterventionsinadultswithtype2diabetes?................3INTERVENTIONSINTERVENTIONSINADULTSInsulindeliveredbycontinuoussubcutaneousBeneficialinfusion......................14Met

2、formin(comparedwithdietaloneorplacebo).......................3UnlikelytobebeneficialSulphonylureas(reduceHbA1ccomparedInsulincomparedwithsulphonylureasaswithplaceboordietalone;newerinitialtreatment(noaddedbenefitandwithsulphonylureasreducehypoglycaemiamorehypoglycaemicepisodesandmorecomparedwithol

3、dersulphonylureas)...5weightgain)....................14LikelytobebeneficialTobecoveredinfutureupdatesEducation(comparedwithusualcare).....7AcarboseIntensivetreatmentprogrammes(comparedInsulinplusoralhypoglycaemicdrugswithusualcare)..................9ThiazolidinedionesMeglitinides(nateglinide,repag

4、linide)....10CoveredelsewhereinClinicalEvidenceTradeoffbetweenbenefitsandharmsGlycaemiccontrolintype1diabetes,p01Combinedoraldrugtreatment(comparedPreventionofcardiovasculareventsinwithmonotherapy)...............11diabetes,p01Insulin(comparedwithcontinuationoforaldrugtreatmentwhereHbA1cisSeeglossa

5、ry
inadequatelycontrolled)...........14UnknowneffectivenessDifferentfrequenciesofselfbloodglucosemonitoring.....................16KeyMessages•Diabetesmellitusisnowseenasaprogressivedisorderofglucosemetabolism,affectingabout5%ofthepopulationworldwide,over85%ofwhomhavetype2diabetes.Type2diabetesmayo

6、ccurwithobesity,hypertensionanddyslipidaemia(themetabolicsyndrome),whicharepowerfulpredictorsofcardiovasculardisease.Bloodglucoselevelsriseprogressivelyovertimeinpeoplewithtype2diabetesregardlessoftreatment,causingmicrovascularandmacrovascularcomplications.•Mostpeoplewithtype2diabeteswilleventuall

7、yneedtreatmentwithoralhypoglycaemicagents.Metforminreducesglycatedhaemoglobinby1−2%,reducesmortalitycomparedwithdietalone,anddoesnotaffectweight,butcancausehypoglycaemia.SulphonylureasreduceHbA1ccomparedwithdieta